ArticlePlant physiology2016
Retrotransposon-Mediated Aluminum Tolerance through Enhanced Expression of the Citrate Transporter OsFRDL4.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 81 citations in OpenAlex.
- Stage-preferential transcriptome profiling reveals senescence associated transcriptional programs linked to nutrient remobilization in rice flag leaves during grain filling.Plant molecular biology · 2026Article
- OsMATE16 Regulates Anther Dehiscence by Modulating IAA Content Under High Temperature.Rice (New York, N.Y.) · 2026Article
- From QTL mapping to genome editing: advances and integrated strategies for improving aluminum tolerance in crops.Frontiers in plant science · 2026Review
- HalALMT1 mediates malate efflux in the cortex of mature cluster rootlets of Hakea laurina, occurring naturally in severely phosphorus-impoverished soil.The New phytologist · 2025Article
- The Role of Low-Molecular-Weight Organic Acids in Metal Homeostasis in Plants.International journal of molecular sciences · 2024Review
- Unlocking plant genetics with telomere-to-telomere genome assemblies.Nature genetics · 2024Review
- Systematic Investigation of Aluminum Stress-Related Genes and Their Critical Roles in Plants.International journal of molecular sciences · 2024Review
- Genome-Wide Identification, Expression Analysis under Abiotic Stress and Co-Expression Analysis ofInternational journal of molecular sciences · 2024Article
- Overexpression of an ART1-Interacting GeneInternational journal of molecular sciences · 2023Article
- Overexpression ofInternational journal of molecular sciences · 2023Article
- Taming transposable elements in livestock and poultry: a review of their roles and applications.Genetics, selection, evolution : GSE · 2023Review
- Metabolome Analysis under Aluminum Toxicity between Aluminum-Tolerant and -Sensitive Rice (Plants (Basel, Switzerland) · 2022Article
- Genome-Wide Identification and Characterisation of WheatInternational journal of molecular sciences · 2022Article
- Cis-regulatory sequences in plants: Their importance, discovery, and future challenges.The Plant cell · 2022Review
- Research Advances in the Mutual Mechanisms Regulating Response of Plant Roots to Phosphate Deficiency and Aluminum Toxicity.International journal of molecular sciences · 2022Review
- Advances in Cereal Crop Genomics for Resilience under Climate Change.Life (Basel, Switzerland) · 2021Review
- How the pan-genome is changing crop genomics and improvement.Genome biology · 2021Review
- Genome-Wide Identification of MATE Gene Family in Potato (Frontiers in genetics · 2021Article
- A single-population GWAS identifiedPlant direct · 2020Article
- Root Adaptation via Common Genetic Factors Conditioning Tolerance to Multiple Stresses for Crops Cultivated on Acidic Tropical Soils.Frontiers in plant science · 2020Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High aluminum (Al) tolerance of rice (Oryza sativa) is controlled by multiple tolerance genes, but the regulatory mechanisms underlying the differential expression of these genes are poorly understood. Here, we investigated the factors regulating the expression of OsFRDL4, a gene encoding a citrate efflux transporter involved in Al-induced citrate secretion from the roots. Analysis with chromosome segment substitution lines derived from cv Nipponbare (high OsFRDL4 expression) and cv Kasalath (low OsFRDL4 expression) revealed that the differential expression of OsFRDL4 is responsible for the quantitative trait locus for Al tolerance detected previously on chromosome 1. Comparison of the OsFRDL4 gene structure in cv Nipponbare and cv Kasalath showed that there was no difference in the position of the transcriptional start site, but a 1.2-kb insertion showing high similarity to the solo long terminal repeat of the retrotransposon was found in the promoter region of OsFRDL4 in cv Nipponbare. This insertion showed higher promoter activity and contained nine cis-acting elements for ALUMINUM RESISTANCE TRANSCRIPTION FACTOR1 (ART1). However, this insertion did not alter the spatial expression or cellular localization of OsFRDL4. Furthermore, this insertion was found in most japonica varieties but was largely absent from indica varieties or wild rice species. These results indicate that the 1.2-kb insertion in the OsFRDL4 promoter region in japonica subspecies is responsible for their higher expression level of OsFRDL4 due to the increased number of cis-acting elements of ART1. Our results also suggest that this insertion event happened at the initial stage of domestication of japonica subspecies.
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