Evidence map›Paper›PMID 27744125›Full record

ArticleJournal of affective disorders2017

Gestational maternal C--reactive protein and risk of bipolar disorder among young individuals in a Nationwide Birth Cohort.

Roshan Chudal, Andre Sourander, Heljä-Marja Surcel, Dan Sucksdorff, Susanna Hinkka-Yli-Salomäki, Alan S Brown

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Roshan ChudalDepartment of Child Psychiatry, University of Turku and Turku University Hospital, Finland. Electronic address: roschu@utu.fi.
Andre SouranderDepartment of Child Psychiatry, University of Turku and Turku University Hospital, Finland.
Heljä-Marja SurcelNational Institute for Health and Welfare, Oulu, Finland.
Dan SucksdorffDepartment of Child Psychiatry, University of Turku and Turku University Hospital, Finland.
Susanna Hinkka-Yli-SalomäkiDepartment of Child Psychiatry, University of Turku and Turku University Hospital, Finland.
Alan S BrownDepartment of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, NY, USA; Department of Epidemiology, Columbia University, Mailman School of Public Health, New York, NY, USA.
University of Turku · FIColumbia University · USFinnish Institute for Health and Welfare · FITurku University Hospital · FI

Funding

Epidemiology of Prenatal Factors and Adult PsychopathologyK02MH065422 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BROWN, ALAN STEWART · 2003 to 2012
$1.2M
NIMH NIH HHS K02 MH065422
6 · The paper itself

Abstract

objectivesC-reactive protein (CRP) is a well-established general marker of inflammation from both infectious and noninfectious exposures. Previous studies have shown that maternal CRP is associated with an increased risk of autism and schizophrenia. The aim of this study was to examine the association between early to mid-gestational serum CRP levels, prospectively assayed in maternal sera, and the risk of bipolar disorder (BPD).

methodsThis study is derived from the Finnish Prenatal Study of Bipolar Disorder (FIPS-B), based on a nested case-control study design. A total of 378 BPD cases and 378 controls, matched on date of birth and sex, with available maternal sera were identified from Finnish nationwide registers. Maternal CRP levels were assessed using a latex immunoassay from archived maternal serum specimens, collected primarily during the first and second trimesters of pregnancy.

resultsIncreasing maternal CRP, examined as a continuous variable, was not associated with BPD (OR=0.92, 95% CI: 0.81-1.05, p=0.24). The result did not change appreciably following adjustment for potential confounders. There were no associations between CRP in the highest quintile or decile, compared with their respective reference groups, and BPD. LIMITATIONS: The limitations of the study include: relative young age of the cohort and availability only of a single marker of inflammation.

conclusionsIn contrast to previous findings on schizophrenia and autism, gestational maternal serum CRP levels were not associated with an increased risk of BPD. It is likely that maternal inflammation may be an additional factor that differentiates schizophrenia from BPD.

Indexed as

AdultBiomarkersBipolar DisorderCase-Control StudiesC-Reactive ProteinFemaleFinlandHumansMalePregnancyPregnancy ComplicationsPregnancy Trimester, SecondRisk FactorsSchizophreniaBiomarkersC-Reactive ProteinBipolar disorderCRPEpidemiologyNationwide cohortPrenatal inflammation

Identifiers

PMID27744125
PMCPMC5154883
OpenAlexW2530102591

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.