Evidence map›Paper›PMID 27743961›Full record

ArticleVirology2016

Mutations in VP1 and 3A proteins improve binding and replication of rhinovirus C15 in HeLa-E8 cells.

Yury A Bochkov, Kelly Watters, Sarmila Basnet, Shakher Sijapati, Marchel Hill, Ann C Palmenberg, James E Gern

Open access · greenAbstract read
In one paragraph

Article in Virology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  5. Article
  6. Pathogens that infect mammalian cells via sulfonated glycosaminoglycans.Frontiers in cellular and infection microbiology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Enhanced Neutralizing Antibody Responses to Rhinovirus C and Age-Dependent Patterns of Infection.American journal of respiratory and critical care medicine · 2021
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yury A BochkovDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: yabochkov@wisc.edu.
Kelly WattersInstitute for Molecular Virology, University of Wisconsin-Madison, Madison, WI, USA.
Sarmila BasnetDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Shakher SijapatiDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA.
Marchel HillInstitute for Molecular Virology, University of Wisconsin-Madison, Madison, WI, USA.
Ann C PalmenbergInstitute for Molecular Virology, University of Wisconsin-Madison, Madison, WI, USA.
James E GernDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
University of Wisconsin–Madison · US

Funding

Inner City Asthma consortium 3 (ICAC3)UM1AI114271 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E., JACKSON, DANIEL J · 2014 to 2021
$79.4M
Virus-Bacterial Interactions and Exacerba of AsthmaP01HL070831 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E. · 2002 to 2017
$31.3M
Wisconsin Infant Study Cohort (WISC)U19AI104317 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTINE Marie SEROOGY · 2013 to 2026
$22.5M
Virology Training ProgramT32AI078985 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI LAMBERT, PAUL F. · 2009 to 2018
$3.3M
NHLBI NIH HHS P01 HL070831NIAID NIH HHS T32 AI078985NIAID NIH HHS U19 AI104317NIAID NIH HHS UM1 AI114271
6 · The paper itself

Abstract

Viruses in the rhinovirus C species (RV-C) can cause severe respiratory illnesses in children including pneumonia and asthma exacerbations. A transduced cell line (HeLa-E8) stably expressing the CDHR3-Y

Indexed as

Mutation, MissenseVirus ReplicationAmino Acid MotifsHeLa CellsHumansPicornaviridae InfectionsRhinovirusViral ProteinsVirus Attachmentviral protein 1, rhinovirusViral ProteinsAdaptationHeparan sulfatePathogenesisReceptor specificityRhinovirus C

Identifiers

PMID27743961
PMCPMC5110265
OpenAlexW2531277457

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.