ArticleEBioMedicine2016
Helicobacter pylori Infection Aggravates Diet-induced Insulin Resistance in Association With Gut Microbiota of Mice.
Article in EBioMedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Altered Gut Microbiota and Short-Chain Fatty Acids After Vonoprazan-Amoxicillin Dual Therapy forFrontiers in cellular and infection microbiology · 2022Trial
- H. pylori eradication with antibiotic treatment causes changes in glucose homeostasis related to modifications in the gut microbiota.PloS one · 2019Trial
- Epidemiological characteristics of Helicobacter pylori infection in Shizuishan and its association with colorectal cancer and the gut microbiota.Tropical medicine and health · 2026Article
- Lipidomics and single-cell transcriptomics uncover aberrant lipid metabolism in metaplasia lesions during gastric carcinogenesis.Journal of gastroenterology · 2026Article
- Longitudinal Association of Inflammatory Diets on Cognition in Older Adults: Insights from the Oral-Gut-Brain Axis.Journal of the American Geriatrics Society · 2025Article
- Sex-specific effects of gastrointestinal microbiome disruptions on Helicobacter pylori-induced gastric carcinogenesis in INS-GAS mice.Biology of sex differences · 2025Article
- Association between triglyceride-glucose index andFrontiers in endocrinology · 2025Article
- Relationship betweenFrontiers in cellular and infection microbiology · 2025Article
- Article
- Helicobacter pylori infection exacerbates metabolic dysfunction-associated steatotic liver disease through lipid metabolic pathways: a transcriptomic study.Journal of translational medicine · 2024Article
- Article
- Article
- Review
- Impact of Dietary Patterns onPathogens (Basel, Switzerland) · 2021Review
- Helicobacter pylori infection worsens impaired glucose regulation in high-fat diet mice in association with an altered gut microbiome and metabolome.Applied microbiology and biotechnology · 2021Article
- The impact ofJournal of diabetes and metabolic disorders · 2020Review
- The Role of Dysfunctional Adipose Tissue in Pancreatic Cancer: A Molecular Perspective.Cancers · 2020Review
- Water extract from processed Polygonum multiflorum modulate gut microbiota and glucose metabolism on insulin resistant rats.BMC complementary medicine and therapies · 2020Article
- Effect of feeding Chinese herb medicine ageratum-liquid on intestinal bacterial translocations induced by H9N2 AIV in mice.Virology journal · 2019Article
- Helicobacter pylori infection, gestational diabetes mellitus and insulin resistance among pregnant Sudanese women.BMC research notes · 2018Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Emerging evidence suggests that Helicobacter pylori infection is associated with insulin resistance (IR) yet the underlying mechanisms are still obscure. The vital role of gut microbiota in triggering IR has been increasingly reported, however, no study has explored the correlation of gut microbiota and H. pylori-associated IR. Using H. pylori-infected mice model fed different diet structures, we demonstrated that H. pylori infection significantly aggravated high-fat diet (HFD)-induced metabolic disorders at the early stage, the extent of which was close to the effect of long-term HFD. Interestingly, we observed dynamic alterations in gut microbiota that were consistent with the changes in the metabolic phenotype induced by H. pylori and HFD. There may be an interaction among H. pylori, diet and gut microbiota, which dysregulates the host metabolic homeostasis, and treatment of H. pylori may be beneficial to the patients with impaired glucose tolerance in addition to diet control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.