ArticleNeuroImage2017
A framework for designing dynamic lp-ntPET studies to maximize the sensitivity to transient neurotransmitter responses to drugs: Application to dopamine and smoking.
Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Modeling PET Data Acquired During Nonsteady Conditions: What If Brain Conditions Change During the Scan?Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Review
- Novel voxelwise residual analysis of [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Kinetic models for estimating occupancy from single-scan PET displacement studies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Striatal dopamine supports reward expectation and learning: A simultaneous PET/fMRI study.NeuroImage · 2023Article
- Assessment of motion and model bias on the detection of dopamine response to behavioral challenge.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Spatiotemporal Kernel Reconstruction for Linear Parametric Neurotransmitter PET Kinetic Modeling in Motion Correction Brain PET of Awake Rats.Frontiers in neuroscience · 2022Article
- NRM 2021 Abstract Booklet.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Assessment of transient dopamine responses to smoked cannabis.Drug and alcohol dependence · 2021Article
- Detecting and classifying neurotransmitter signals from ultra-high sensitivity PET data: the future of molecular brain imaging.Physics in medicine and biology · 2021Article
- A Monte Carlo approach for improving transient dopamine release detection sensitivity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Model Comparison Metrics Require Adaptive Correction if Parameters Are Discretized: Proof-of-Concept Applied to Transient Signals in Dynamic PET.IEEE transactions on medical imaging · 2020Article
- Methods for Quantifying Neurotransmitter Dynamics in the Living Brain With PET Imaging.Frontiers in physiology · 2020Review
- Toward whole-brain dopamine movies: a critical review of PET imaging of dopamine transmission in the striatum and cortex.Brain imaging and behavior · 2019Review
- Dynamic image denoising for voxel-wise quantification with Statistical Parametric Mapping in molecular neuroimaging.PloS one · 2018Article
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4 authors.
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Abstract
The "linear parametric neurotransmitter PET" (lp-ntPET) model was introduced to capture the time course of transient endogenous neurotransmitter response to drug stimulus from dynamic PET data. We previously used this novel analysis tool to probe the short-lived dopamine (DA) response induced by cigarette smoking in the PET scanner. It allowed us to find a sex difference in the DA signature of cigarette smoking. To make best use of this tool to characterize neurotransmitter response to drug stimulus, the sensitivity of lp-ntPET to detect such responses must be maximized. We designed a series of simulation studies to examine the impact of the following factors on the sensitivity of lp-ntPET using smoking-induced DA release as an example application: tracer delivery protocol, pre-processing for image denoising, timing of the smoking task, duration of the PET scan, and dose of the radiotracer. Our results suggest that a Bolus paradigm could replace a more difficult B/I paradigm without sacrificing the sensitivity of the method. Pre-processing the PET data with the de-noising algorithm HYPR could improve the sensitivity. The optimal timing to start the smoking task is 45min in a 90min scan and 35min in a 75min scan. A mild shortening of the scan time from 90mCi to 75min should be acceptable without loss of sensitivity. We suggest a lower dose limit of a bolus injection at 16mCi to limit underestimation of DA activation. This study established the framework to optimize the experimental design for reaching the full potential of lp-ntPET to detect neurotransmitter responses to drugs or even behavioral tasks.
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