Evidence map›Paper›PMID 27743777›Full record

ReviewTrends in immunology2016

Antigen Presentation in Transplantation.

Maria-Luisa Alegre, Fadi G Lakkis, Adrian E Morelli

Abstract readReview
In one paragraph

Review in Trends in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. The search for peripheral tolerance in lung transplantation.Current opinion in pulmonary medicine · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Alloreactive memory CD4 T cells promote transplant rejection by engaging DCs to induce innate inflammation and CD8 T cell priming.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Maria-Luisa AlegreDepartment of Medicine, University of Chicago, 924 East 57th Street, JFK-R312, Chicago, IL 60637, USA. Electronic address: malegre@midway.uchicago.edu.
Fadi G LakkisThomas E. Starzl Transplantation Institute and Departments of Surgery and Immunology, University of Pittsburgh School of Medicine, Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA; Thomas E. Starzl Transplantation Institute and Department of Medicine, University of Pittsburgh School of Medicine, Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA.
Adrian E MorelliThomas E. Starzl Transplantation Institute and Departments of Surgery and Immunology, University of Pittsburgh School of Medicine, Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15261, USA.

Funding

T cell mechanisms that distinguish robust tolerance from metastable allograft acceptance and failed tolerance (Project 2)P01AI097113 · NIAID · UNIVERSITY OF CHICAGO · PI Maria-Luisa Alegre, Anita S Chong · 2012 to 2026
$23.8M
T Cell Memory in Organ TransplantationR01AI049466 · NIAID · YALE UNIVERSITY · PI LAKKIS, FADI G. · 2001 to 2024
$7.5M
Impact of Microbiota on Alloimmune Responses in TransplantationR01AI115716 · NIAID · UNIVERSITY OF CHICAGO · PI ALEGRE, MARIA-LUISA · 2015 to 2024
$4.3M
Innate Recognition of Allogeneic Non-SelfR01AI099465 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAKKIS, FADI G. · 2012 to 2022
$4.1M
HL Exosomes as paracrine signal mediators in cardiac allograft rejectionR01HL130191 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MORELLI, ADRIAN E. · 2016 to 2019
$1.5M
NHLBI NIH HHS R01 HL130191NIAID NIH HHS P01 AI097113NIAID NIH HHS R01 AI049466NIAID NIH HHS R01 AI099465NIAID NIH HHS R01 AI115716
6 · The paper itself

Abstract

Transplantation of solid organs between genetically distinct individuals leads, in the absence of immunosuppression, to T cell-dependent transplant rejection. Activation of graft-reactive T cells relies on the presentation of transplant-derived antigens (intact donor MHC molecules or processed peptides on host MHC molecules) by mature dendritic cells (DCs). This review focuses on novel insights regarding the steps for maturation and differentiation of DCs that are necessary for productive presentation of transplant antigens to host T cells. These steps include the licensing of DCs by the microbiota, their activation and maturation following recognition of allogeneic non-self, and their capture of donor cell exosomes to amplify the presentation of transplant antigens.

Indexed as

Antigen PresentationOrgan TransplantationTransplantation ImmunologyAnimalsCell DifferentiationDendritic CellsExosomesGraft RejectionHumansIsoantigensLymphocyte ActivationMicrobiotaT-LymphocytesTransplantation ToleranceIsoantigens

Identifiers

PMID27743777
PMCPMC5135637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.