SynthesisSchizophrenia research2017
Meta-analysis of glucose tolerance, insulin, and insulin resistance in antipsychotic-naïve patients with nonaffective psychosis.
Synthesis in Schizophrenia research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 9 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 9 syntheses or guidelines pooled it, 116 citations in OpenAlex.
- Altered function of peripheral organ systems in first-episode drug naïve mental illnesses: a systematic review and meta-analysis.Molecular psychiatry · 2026Pooled it
- Allostatic load index across the psychosis spectrum: a systematic review and meta-analysis.Frontiers in psychiatry · 2025Pooled it
- Variability of glucose, insulin, and lipid disturbances in first-episode psychosis: a meta-analysis.Psychological medicine · 2023Pooled it
- Changes in peripheral blood compounds following psychopharmacological treatment in drug-naïve first-episode patients with either schizophrenia or major depressive disorder: a meta-analysis.Psychological medicine · 2021Pooled it
- Antipsychotic Exposure in Pregnancy and the Risk of Gestational Diabetes: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2020Pooled it
- Glucose metabolism dysregulation at the onset of mental illness is not limited to first episode psychosis: A systematic review and meta-analysis.Early intervention in psychiatry · 2019Pooled it
- Is psychosis a multisystem disorder? A meta-review of central nervous system, immune, cardiometabolic, and endocrine alterations in first-episode psychosis and perspective on potential models.Molecular psychiatry · 2019Pooled it
- Atypical antipsychotics, insulin resistance and weight; a meta-analysis of healthy volunteer studies.Progress in neuro-psychopharmacology & biological psychiatry · 2018Pooled it
- Cholesterol and triglyceride levels in first-episode psychosis: systematic review and meta-analysis.The British journal of psychiatry : the journal of mental science · 2017Pooled it
- Effect of lurasidone versus olanzapine on cardiometabolic parameters in unmedicated patients with schizophrenia: a randomized controlled trial.Psychopharmacology · 2020Trial
- Sex-specific differences in the relationship between prolactin and glucose metabolism in first-episode schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Impact of severe anxiety, depression, and their comorbidity on glucose metabolism in first-episode antipsychotic-naïve schizophrenia patients.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Immunometabolic reprogramming of central and peripheral immune cells in mental disorders: mechanisms and therapeutic implications.Frontiers in immunology · 2026Review
- Impaired Glucose Metabolism in Young Patients with First-episode Schizophrenia Aged from 16 to 35 Years.Current neuropharmacology · 2026Article
- Insulin resistance in patients with schizophrenia: is it related to gut permeability?Schizophrenia (Heidelberg, Germany) · 2025Article
- Epiphenomena in psychosis: how perinatal stressful events shape long-term outcomes.Molecular psychiatry · 2025Review
- Cardiovascular protein profiling in patients with first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2025Article
- Cardiovascular Disease Markers in Schizophrenia During Negative Symptoms and Remission Periods.Journal of clinical medicine · 2025Article
- Physical illness in schizophrenia and the role of tolerability in antipsychotic selection: an expert consensus with a focus on cariprazine.Annals of general psychiatry · 2025Review
- Neuronal Synaptic Communication and Mitochondrial Energetics in Human Health and Disease.Advances in experimental medicine and biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundSome studies have suggested that antipsychotic-naïve patients with nonaffective psychosis (NAP) have glucose intolerance.
aimsTo conduct a systematic review and meta-analysis of fasting glucose (FG), two hour values in the oral glucose tolerance test (2HG), fasting insulin concentration (INS), and insulin resistance (IR).
methodWe identified possibly relevant studies, then selected studies, following usual guidelines, with two authors reviewing the manuscripts. We required studies to include subjects with nonaffective psychosis and control subjects.
resultsThere were 911 patients and 870 control subjects in the analysis of FG; their average ages were respectively 28.7 and 29.5years. Significant differences were found for all four variables, with effect size estimates ranging from 0.21 to 0.58.
conclusionsAs a group, at the time of first clinical contact for psychosis, people with NAP have a slight increase in FG, which most of them maintain in the normal range despite a small increase in IR by secreting additional INS. When faced with a physiological challenge such as a glucose tolerance test or antipsychotics, they are no longer able to maintain a normal glucose concentration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.