ArticleJournal of biomechanics2016
Characterising the effects of in vitro mechanical stimulation on morphogenesis of developing limb explants.
Article in Journal of biomechanics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Determining Which Hydrostatic Pressure Regimes Promote Osteogenesis in Human Mesenchymal Stem Cells.Tissue engineering and regenerative medicine · 2024Article
- YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulation in murine bone development.Developmental cell · 2024Article
- Mechanical loading due to muscle movement regulates establishment of the collagen network in the developing murine skeleton.Royal Society open science · 2023Article
- Rapid specialization and stiffening of the primitive matrix in developing articular cartilage and meniscus.Acta biomaterialia · 2023Article
- Mechanoregulatory role of TRPV4 in prenatal skeletal development.Science advances · 2023Article
- YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulated bone development.bioRxiv : the preprint server for biology · 2023Article
- Design of a Bioreactor to Assess the Effect of Passive Joint Loading in a Live Chick EmbryoTissue engineering. Part C, Methods · 2019Article
- Blocking mechanosensitive ion channels eliminates the effects of applied mechanical loading on chick joint morphogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Altered biomechanical stimulation of the developing hip joint in presence of hip dysplasia risk factors.Journal of biomechanics · 2018Article
- Stresses and strains on the human fetal skeleton during development.Journal of the Royal Society, Interface · 2018Article
- Changing While Staying the Same: Preservation of Structural Continuity During Limb Evolution by Developmental Integration.Integrative and comparative biology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mechanical forces due to fetal movements play an important role in joint shape morphogenesis, and abnormalities of the joints relating to abnormal fetal movements can have long-term health implications. While mechanical stimulation during development has been shown to be important for joint shape, the relationship between the quantity of mechanical stimulation and the growth and shape change of developing cartilage has not been quantified. In this study, we culture embryonic chick limb explants in vitro in order to reveal how the magnitude of applied movement affects key aspects of the developing joint shape. We hypothesise that joint shape is affected by movement magnitude in a dose-dependent manner, and that a movement regime most representative of physiological fetal movements will promote characteristics of normal shape development. Chick hindlimbs harvested at seven days of incubation were cultured for six days, under either static conditions or one of three different dynamic movement regimes, then assessed for joint shape, cell survival and proliferation. We demonstrate that a physiological magnitude of movement in vitro promotes the most normal progression of joint morphogenesis, and that either under-stimulation or over-stimulation has detrimental effects. Providing insight into the optimal level of mechanical stimulation for cartilage growth and morphogenesis is pertinent to gaining a greater understanding of the etiology of conditions such as developmental dysplasia of the hip, and is also valuable for cartilage tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.