Trial reportEpilepsy & behavior : E&B2016
Targeted Self-Management of Epilepsy and Mental Illness for individuals with epilepsy and psychiatric comorbidity.
Trial report in Epilepsy & behavior : E&B, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07628647 (Pilot Study of the Living Well With Brain Cancer Intervention), which is not on this map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study of the Living Well With Brain Cancer Intervention
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Efficacy of psychological and behavioral interventions for depressive symptoms in people with epilepsy: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Correlates of quality of life among individuals with epilepsy enrolled in self-management research: From the US Centers for Disease Control and Prevention Managing Epilepsy Well Network.Epilepsy & behavior : E&B · 2017Pooled it
- Clinical correlates of perceived stigma among people living with epilepsy enrolled in a self-management clinical trial.Epilepsy & behavior : E&B · 2024Trial
- A multicenter randomized controlled feasibility trial of a digital self-management intervention for adults with epilepsy.Epilepsia open · 2024Trial
- Effects of a remotely delivered group-format epilepsy self-management program on adverse health outcomes in vulnerable people with epilepsy: A causal mediation analysis.Epilepsy research · 2020Trial
- Trial
- Factors influencing self-management in patients with epilepsy: a systematic review and meta-analysis.BMC nursing · 2025Article
- Article
- MEW network self-management program characteristics and lessons learned through the RE-AIM framework.Epilepsy & behavior : E&B · 2023Article
- Factors associated with stress-related symptoms among people with epilepsy in Ethiopia, a cross-sectional study.Frontiers in neurology · 2023Article
- Article
- Baicalin Rescues Cognitive Dysfunction, Mitigates Neurodegeneration, and Exerts Anti-Epileptic Effects Through Activating TLR4/MYD88/Caspase-3 Pathway in Rats.Drug design, development and therapy · 2021Article
- Psychological treatments for people with epilepsy.The Cochrane database of systematic reviews · 2020Review
- Correlates of Stigma in People with Epilepsy.Journal of clinical neurology (Seoul, Korea) · 2020Article
- Bridging the divide between epilepsy and mental health to drive solutions.Epilepsy & behavior : E&B · 2019Article
- Self-management for adults with epilepsy: Aggregate Managing Epilepsy Well Network findings on depressive symptoms.Epilepsia · 2019Article
- Depression and quality of life among African Americans with epilepsy: Findings from the Managing Epilepsy Well (MEW) Network integrated database.Epilepsy & behavior : E&B · 2019Article
- Depressive Symptoms in Older versus Younger People with Epilepsy: Findings from an Integrated Epilepsy Self-Management Clinical Research Dataset.Journal of multidisciplinary healthcare · 2019Article
- The Community-targeted Self-management of Epilepsy and Mental Illness (C-TIME) initiative: A research, community, and healthcare administration partnership to reduce epilepsy burden.Epilepsy & behavior : E&B · 2018Article
- Demographic and Clinical Correlates of Seizure Frequency: Findings from the Managing Epilepsy Well Network Database.Journal of clinical neurology (Seoul, Korea) · 2018Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesSerious mental illness is disproportionately common in people with epilepsy and contributes to complications and mortality. Few care approaches specifically target individuals who have epilepsy and severe mental illness. We used an iterative process to refine an existing intervention and tested the novel intervention, Targeted Self-Management for Epilepsy and Mental Illness (TIME) in individuals with epilepsy and comorbid mental illness (E-MI).
methodsThe TIME intervention was developed with input from a community advisory board and then tested for feasibility, acceptability, and preliminary efficacy in people with E-MI, using a 16-week prospective, randomized controlled design comparing TIME (N=22) vs. treatment as usual (TAU, N=22). Primary outcome was change in depressive symptoms, assessed by the Montgomery Asberg Depression Rating Scale (MADRS). Secondary assessments included global psychiatric symptom severity, seizure frequency, sleep patterns, quality of life, stigma, social support, and self-efficacy.
resultsThere were 44 individuals enrolled, mean age 48.25 (SD=11.82) with 25 (56.8%) African-Americans. The majority (N=31, 70.5%) were unemployed, and most (N=41, 95.5%) had annual income <U.S. $25,000. With respect to study retention, there were 36 individuals (18 in TIME, 18 in TAU) assessed at 12weeks and 35 individuals (19 in TIME, 16 in TAU) assessed at 16weeks. There was a significant effect for MADRS (p=0.036; effect size of 0.70), with lower MADRS at 16weeks in TIME, while TAU MADRS did not change. Differences between most secondary measures were not statistically significant. SIGNIFICANCE: The TIME intervention engages individuals to actively participate in self-management and can reduce depression in E-MI. Given the high morbidity and mortality associated with epilepsy complicated by serious mental illness, additional research is needed to better identify how TIME might be implemented in routine care settings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.