Evidence map›Paper›PMID 27743539›Full record

ReviewCurrent opinion in genetics & development2016

Integrating the signatures of demic expansion and archaic introgression in studies of human population genomics.

Lauren Alpert Sugden, Sohini Ramachandran

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lauren Alpert SugdenCenter for Computational Molecular Biology, Brown University, Providence, RI, USA; Department of Ecology and Evolutionary Biology, Brown University, Providence, RI, USA.
Sohini RamachandranCenter for Computational Molecular Biology, Brown University, Providence, RI, USA; Department of Ecology and Evolutionary Biology, Brown University, Providence, RI, USA. Electronic address: sramachandran@brown.edu.

Funding

The role of Sirtuins in neurodegenerative diseaseP20GM109035 · NIGMS · BROWN UNIVERSITY · PI LIU, YAJUN · 2016 to 2025
$22.6M
Novel statistical methods to localize genomic elements underlying adaptive evolutionR01GM118652 · NIGMS · BROWN UNIVERSITY · PI RAMACHANDRAN, SOHINI · 2016 to 2020
$1.6M
NIGMS NIH HHS P20 GM109035NIGMS NIH HHS R01 GM118652
6 · The paper itself

Abstract

Human population genomic studies have repeatedly observed a decrease in heterozygosity and an increase in linkage disequilibrium with geographic distance from Africa. While multiple demographic models can generate these patterns, many studies invoke the serial founder effect model, in which populations expand from a single origin and each new population's founders represent a subset of genetic variation in the previous population. The model assumes no admixture with archaic hominins, however, recent studies have identified loci in Homo sapiens bearing signatures of archaic introgression. These results appear to contradict the validity of analyses invoking the serial founder effect model, but we show these two perspectives are compatible. We also propose using the serial founder effect model as a null model for determining the signature of archaic admixture in modern human genomes at different geographic and genomic scales.

Indexed as

Genetics, PopulationMetagenomicsAfricaAnimalsGenetic VariationGenome, HumanGeographyHominidaeHumansLinkage Disequilibrium

Identifiers

PMID27743539
PMCPMC5161554

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.