Evidence map›Paper›PMID 27743488›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2017

Effect of Lung Transplantation on Health-Related Quality of Life in the Era of the Lung Allocation Score: A U.S. Prospective Cohort Study.

J P Singer, P P Katz, A Soong, P Shrestha, D Huang, J Ho, M Mindo, J R Greenland, S R Hays, J Golden and 4 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04469842 (A Prospective, Randomized, Controlled Pilot Study of Early-Use Long Acting Tacrolimus), which is not on this map. Cited by 57 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 2 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04469842 early_phase1recruitingnot on this mapstarted 2023, after this paper: background citation

A Prospective, Randomized, Controlled Pilot Study of Early-Use Long Acting Tacrolimus (Envarsus XR) in Lung Transplant Recipients

TypeinterventionalSponsorVanderbilt University Medical CenterRan2023 to 2027Enrolled48ConditionsLung Transplant, ComplicationsArmsTacrolimus Extended Release Oral Tablet [Envarsus], Tacrolimus, Mycophenolate Mofetil Hydrochloride, Prednisone, Azathioprine
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Timing of quality of life and lung function changes during the first year following lung transplantation: A multicenter prospective cohort study.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026
    Observational
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  7. Observational
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  11. Review
  12. The histone demethylase KDM6B links obstructive sleep apnea to idiopathic pulmonary fibrosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  13. Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

J P SingerDepartment of Medicine, University of California, San Francisco, CA.
P P KatzDepartment of Medicine, University of California, San Francisco, CA.
A SoongDepartment of Medicine, University of California, San Francisco, CA.
P ShresthaDepartment of Medicine, University of California, San Francisco, CA.
D HuangDepartment of Medicine, University of California, San Francisco, CA.
J HoDepartment of Medicine, University of California, San Francisco, CA.
M MindoDepartment of Medicine, University of California, San Francisco, CA.
J R GreenlandDepartment of Medicine, University of California, San Francisco, CA.ORCID http://orcid.org/0000-0003-1422-8367
S R HaysDepartment of Medicine, University of California, San Francisco, CA.
J GoldenDepartment of Medicine, University of California, San Francisco, CA.
J KukrejaDepartment of Surgery, University of California, San Francisco, CA.
M E KleinhenzDepartment of Medicine, University of California, San Francisco, CA.
R J ShahDepartment of Medicine, University of California, San Francisco, CA.
P D BlancDepartment of Medicine, University of California, San Francisco, CA.
University of California, San Francisco · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
The Effects of Lung Transplant on Disability and Health-Related Quality of LifeK23HL111115 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SINGER, JONATHAN PAUL · 2012 to 2016
$832k
Immune Mechanisms of Large-airway Lymphocytic BronchitisIK2CX001034 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI GREENLAND, JOHN · 2015 to 2019
–
CSRD VA IK2 CX001034NCRR NIH HHS UL1 RR024131NHLBI NIH HHS K23 HL111115
6 · The paper itself

Abstract

Under the U.S. Lung Allocation Score (LAS) system, older and sicker patients are prioritized for lung transplantation (LT). The impact of these changes on health-related quality of life (HRQL) after transplant has not been determined. In a single-center prospective cohort study from 2010 to 2016, we assessed HRQL before and repeatedly after LT for up to 3 years using the SF12-Physical and Mental Health, the respiratory-specific Airway Questionnaire 20-Revised, and the Euroqol 5D/Visual Analog Scale utility measures by multivariate linear mixed models jointly modeled with death. We also tested changes in LT-Valued Life Activities disability, BMI, allograft function, and 6-min walk test exercise capacity as predictors of HRQL change. Among 211 initial participants (92% of those eligible), LT improved HRQL by all 5 measures (p < 0.05) and all but SF12-Mental Health improved by threefold or greater than the minimally clinically important difference. Compared to younger participants, those aged ≥65 improved less in SF12-Physical and Mental Health (p < 0.01). Improvements in disability accounted for much of the HRQL improvement. In the LAS era, LT affords meaningful and durable HRQL improvements, mediated by amelioration of disability. Identifying factors limiting HRQL improvement in selected subgroups, especially those aged ≥65, are needed to maximize the net benefits of LT.

Indexed as

Health Care RationingLung TransplantationQuality of LifeResource AllocationAdolescentAdultAgedFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedPrognosisProspective StudiesQuality-Adjusted Life Yearsclinical decision-makingclinical research/practiceepidemiologygeriatricslung transplantation/pulmonologyorgan allocationquality of life (QOL)

Identifiers

PMID27743488
PMCPMC6085872
OpenAlexW2531736197

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.