Evidence map›Paper›PMID 27743374›Full record

ArticleBrain imaging and behavior2017

Associations between genetic risk, functional brain network organization and neuroticism.

Michelle N Servaas, Linda Geerligs, Jojanneke A Bastiaansen, Remco J Renken, Jan-Bernard C Marsman, Ilja M Nolte, Johan Ormel, André Aleman, Harriëtte Riese

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain imaging and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Associations Between Daily Affective Instability and Connectomics in Functional Subnetworks in Remitted Patients with Recurrent Major Depressive Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Michelle N ServaasNeuroimaging Center, Department of Neuroscience, University of Groningen, University Medical Center Groningen, PO Box 196, 9700, AD, Groningen, the Netherlands. m.n.servaas@umcg.nl.
Linda GeerligsMRC Cognition and Brain Sciences Unit, University of Cambridge, 15 Chaucer Road, Cambridge, CB2 7EF, UK.
Jojanneke A BastiaansenInterdisciplinary Center for Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700, RB, Groningen, the Netherlands.
Remco J RenkenNeuroimaging Center, Department of Neuroscience, University of Groningen, University Medical Center Groningen, PO Box 196, 9700, AD, Groningen, the Netherlands.
Jan-Bernard C MarsmanNeuroimaging Center, Department of Neuroscience, University of Groningen, University Medical Center Groningen, PO Box 196, 9700, AD, Groningen, the Netherlands.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700, RB, Groningen, the Netherlands.
Johan OrmelInterdisciplinary Center for Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700, RB, Groningen, the Netherlands.
André AlemanNeuroimaging Center, Department of Neuroscience, University of Groningen, University Medical Center Groningen, PO Box 196, 9700, AD, Groningen, the Netherlands.
Harriëtte RieseInterdisciplinary Center for Psychopathology and Emotion regulation, Department of Psychiatry, University of Groningen, University Medical Center Groningen, PO Box 30.001, 9700, RB, Groningen, the Netherlands.
University Medical Center Groningen · NLUniversity of Groningen · NLUniversity of Cambridge · GB

Funding

Ministerie van Onderwijs, Cultuur en Wetenschap 609022
6 · The paper itself

Abstract

Neuroticism and genetic variation in the serotonin-transporter (SLC6A4) and catechol-O-methyltransferase (COMT) gene are risk factors for psychopathology. Alterations in the functional integration and segregation of neural circuits have recently been found in individuals scoring higher on neuroticism. The aim of the current study was to investigate how genetic risk factors impact functional network organization and whether genetic risk factors moderate the association between neuroticism and functional network organization. We applied graph theory analysis on resting-state fMRI data in a sample of 120 women selected based on their neuroticism score, and genotyped two polymorphisms: 5-HTTLPR (S-carriers and L-homozygotes) and COMT (rs4680-rs165599; COMT risk group and COMT non-risk group). For the 5-HTTLPR polymorphism, we found that subnetworks related to cognitive control show less connections with other subnetworks in S-carriers compared to L-homozygotes. The COMT polymorphism moderated the association between neuroticism and functional network organization. We found that neuroticism was associated with lower efficiency coefficients in visual and somatosensory-motor subnetworks in the COMT risk group compared to the COMT non-risk group. The findings of altered topology of specific subnetworks point to different cognitive-emotional processes that may be affected in relation to the genetic risk factors, concerning emotion regulation in S-carriers (5-HTTLPR) and emotional salience processing in COMT risk carriers.

Indexed as

NeuroticismPolymorphism, Single NucleotideAdolescentAdultBrainBrain MappingCatechol O-MethyltransferaseFemaleGenetic Association StudiesHeterozygoteHumansMagnetic Resonance ImagingRestSerotonin Plasma Membrane Transport ProteinsYoung AdultCatechol O-MethyltransferaseCOMT protein, humanSerotonin Plasma Membrane Transport ProteinsSLC6A4 protein, humanFunctional connectivityGeneticsGraph theoryPersonalityResting-state functional magnetic resonance imaging (rs-fMRI)

Identifiers

PMID27743374
PMCPMC5707236
OpenAlexW2530465144

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.