ArticlePituitary2017
Time trends of mortality in patients with non-functioning pituitary adenoma: a Swedish nationwide study.
Article in Pituitary, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Excess mortality in radiotherapy-treated pituitary adenoma patients: 50-year follow-up.Journal of the Endocrine Society · 2026Article
- Prognostic factors in the surgical treatment of non-functioning pituitary adenomas: a retrospective cohort study.Archives of endocrinology and metabolism · 2026Article
- Impact of sex on mortality in patients with pituitary adenomas.Pituitary · 2026Review
- Increased mortality in patients with non-functioning pituitary tumors: a study in a tertiary center.Frontiers in endocrinology · 2025Article
- Association between Preoperative Medication Lists and Postoperative Hospital Length of Stay after Endoscopic Transsphenoidal Pituitary Surgery.Journal of clinical medicine · 2022Article
- Size Matters: Rethinking of the Sizing Classification of Pituitary Adenomas Based on the Rates of Surgery: A Multi-institutional Retrospective Study of 29,651 Patients.Journal of neurological surgery. Part B, Skull base · 2022Article
- Growth hormone deficiency and replacement therapy in adults: Impact on survival.Reviews in endocrine & metabolic disorders · 2021Review
- Non-functioning pituitary adenomas: indications for pituitary surgery and post-surgical management.Pituitary · 2019Review
- Socioeconomic Predictors of Pituitary Surgery.Cureus · 2019Article
- Recurrent non-functioning pituitary adenomas: a review on the new pathological classification, management guidelines and treatment options.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018Review
- Mortality in patients with non-functioning pituitary adenoma.Pituitary · 2018Review
- Hypopituitarism-needs modern individualized treatment.Endocrine · 2017Article
- STEREOTACTIC RADIATION THERAPY IN PITUITARY ADENOMAS, IS IT BETTER THAN CONVENTIONAL RADIATION THERAPY?Acta endocrinologica (Bucharest, Romania : 2005)Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePatients with non-functioning pituitary adenomas (NFPA), especially women, have increased mortality. The aim of this study was to investigate whether mortality in NFPA patients has changed during the last two decades.
methodsThis was a nationwide population-based study including 2795 patients (1502 men, 1293 women) diagnosed with NFPA between 1997 and 2011. Patients were identified and followed in Swedish National Health Registries. Standardized mortality ratios (SMRs) with 95 % confidence intervals were calculated for three time periods at first NFPA diagnosis using the general population as reference.
resultsMean (±SD) age at NFPA diagnosis was 58.9 ± 16.8 years. Mean (range) follow-up time was 8.3 (0-18) years, resulting in 20,517 patient-years at risk. Surgical treatment and radiotherapy were used in 53 and 5 %, respectively. The prevalence of hypopituitarism was 64 % during the first time period of diagnosis and then declined gradually during the study period (P value for trend <0.0001). The use of pituitary surgery and radiotherapy remained stable. In women, mortality was increased for patients diagnosed between 1997 and 2006 but not for those diagnosed between 2007 and 2011. The SMR in men remained stable throughout the study and did not differ from the general population. During the last time period, 2007-2011, the SMR between men and women did not differ.
conclusionsWhile mortality in men with NFPA remains normal and stable during the last two decades, mortality in women has declined. Decreasing prevalence of pituitary insufficiency may be a plausible explanation for this positive development.
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