Evidence map›Paper›PMID 27743128›Full record

ArticleImmunologic research2017

New automated indirect immunofluorescent antinuclear antibody testing compares well with established manual immunofluorescent screening and titration for antinuclear antibody on HEp-2 cells.

M Daves, J Blecken, T Matthias, A Frey, V Perkmann, A Dall Acqua, A Joos, S Platzgummer

Abstract read
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Article in Immunologic research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

M DavesClinical Pathology Laboratory, Hospital of Merano, Via Rossini 5, 39011, Merano, Italy. massimo.daves@sabes.it.
J BleckenAESKU.DIAGNOSTICS, Mikroforum Ring 2, 55234, Wendelsheim, Germany.
T MatthiasAESKU.DIAGNOSTICS, Mikroforum Ring 2, 55234, Wendelsheim, Germany.
A FreyAESKU.DIAGNOSTICS, Mikroforum Ring 2, 55234, Wendelsheim, Germany.
V PerkmannClinical Pathology Laboratory, Hospital of Merano, Via Rossini 5, 39011, Merano, Italy.
A Dall AcquaClinical Pathology Laboratory, Hospital of Merano, Via Rossini 5, 39011, Merano, Italy.
A JoosClinical Pathology Laboratory, Hospital of Merano, Via Rossini 5, 39011, Merano, Italy.
S PlatzgummerClinical Pathology Laboratory, Hospital of Merano, Via Rossini 5, 39011, Merano, Italy.
Krankenhaus Meran · ITCS Diagnostics · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The IIF using the HEp-2 cell substrate should be still considered the "gold standard" techniques for determination of antinuclear antibody (ANA). Standardization and automation can be considered to be still in progress. Aim of this study was to evaluate the performance of the commercially automated indirect immunofluorescent antinuclear HEp-2 antibody assay. The study was designed to compare two commercially available HEp-2 ANA by indirect immunofluorescent antibody assays using a sensitivity panel (120 clinically determined patients) and a specificity panel consisting of 78 clinically confirmed negative patients. We compared the NOVA View

Indexed as

Antibodies, AntinuclearAutoimmune DiseasesAutomation, LaboratoryCell Line, TumorFluorescent Antibody Technique, IndirectHumansSensitivity and SpecificityAntibodies, AntinuclearAntinuclear antibodyAutoimmune diseasesAutomated systemsHEp-2 cellIndirect immunofluorescent techniques

Identifiers

PMID27743128
OpenAlexW2530406466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.