ReviewPediatric surgery international2017
Pediatric appendicitis: state of the art review.
Review in Pediatric surgery international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04986397 (Cold Therapy For Pain Control Among Pediatric Appendectomy Patients), which is not on this map. Cited by 59 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cold Therapy For Pain Control Among Pediatric Appendectomy Patients: A Randomized Controlled Trial
Who cites it
59 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effectiveness and Safety of Shortened Postoperative Antibiotic Regimens in Children with Perforated Appendicitis: A Systematic Review and Meta-Analysis.European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie · 2026Pooled it
- Clinical efficacy and safety of endoscopic retrograde appendicitis treatment for acute appendicitis in children: a systematic review and meta-analysis.World journal of emergency surgery : WJES · 2025Pooled it
- Non-operative management of uncomplicated appendicitis in children, why not? A meta-analysis of randomized controlled trials.World journal of emergency surgery : WJES · 2025Pooled it
- Swedish national guidelines for diagnosis and management of acute appendicitis in adults and children.BJS open · 2025Guideline
- Demographic and Clinical Characteristics Associated With the Failure of Nonoperative Management of Uncomplicated Appendicitis in Children: Secondary Analysis of a Nonrandomized Clinical Trial.JAMA network open · 2022Trial
- The modified endoscopic retrograde appendicitis therapy versus antibiotic therapy alone for acute uncomplicated appendicitis in children.Surgical endoscopy · 2021Trial
- Reply to Sridharan K et al.Pediatric radiology · 2026Article
- Potential value of incorporating full clinical data in vision-language model studies for pediatric appendicitis: reply to Mese et al.Pediatric radiology · 2026Article
- Prevalence and Preoperative Characteristics Associated with Complicated Appendicitis Among Children Undergoing Appendectomy in Southwestern Saudi Arabia: A Hospital-Based Cross-Sectional Study.Children (Basel, Switzerland) · 2026Article
- Health Care Utilization and Pediatric Appendicitis: Insights From an Integrated Health System.The Permanente journal · 2026Article
- Impact of a diagnostic strategy for appendicitis in children with acute abdominal pain in primary care: study protocol for a hybrid type 1 cluster randomised controlled trial.Diagnostic and prognostic research · 2026Review
- Incremental diagnostic value of HSP-70, presepsin, and HO-1 for differentiating acute appendicitis from nonsurgical abdominal pain in children: a prospective cohort study.BMC pediatrics · 2026Article
- Cholangioscope-assisted endoscopic retrograde appendicitis therapy for pediatric acute uncomplicated appendicitis.Pediatric surgery international · 2026Article
- Differentiating Uncomplicated From Complicated Acute Appendicitis in Paediatric Patients With C-Reactive Protein and Imaging Findings-A Retrospective Single Centre Study in 1149 Patients.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Complete subserosal embedding of the appendix-cecal complex presenting as a non-visualized appendix during pediatric laparoscopic appendectomy: a case report.Frontiers in surgery · 2026Article
- The impact of pediatric constipation on appendicitis: a prospective birth cohort in the Japan Environment and Children's Study.BMC pediatrics · 2025Article
- Comparison of the efficacy of carbapenems and cephalosporins for postoperative treatment of perforated appendicitis in children.World journal of gastrointestinal surgery · 2025Article
- External validation of predictive models for diagnosis, management and severity of pediatric appendicitis.Frontiers in pediatrics · 2025Article
- Repeat ultrasound in pediatric EDs improves appendicitis diagnosis after referral imaging.Frontiers in pediatrics · 2025Article
- Risk Factors for Postoperative Intra-Abdominal Abscess in Pediatric Perforated Appendicitis Following Laparoscopic Appendectomy: A Multicenter Analysis.Children (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Appendicitis is a common cause of abdominal pain in children. The diagnosis and treatment of the disease have undergone major changes in the past two decades, primarily as a result of the application of an evidence-based approach. Data from several randomized controlled trials, large database studies, and meta-analyses have fundamentally affected patient care. The best diagnostic approach is a standardized clinical pathway with a scoring system and selective imaging. Non-operative management of simple appendicitis is a reasonable option in selected cases, with the caveat that data in children remain limited. A minimally invasive (laparoscopic) appendectomy is the current standard in US and European children's hospitals. This article reviews the current 'state of the art' in the evaluation and management of pediatric appendicitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.