Evidence map›Paper›PMID 27742916›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2016

The contribution of depressive symptoms to slowness of information processing in relapsing remitting multiple sclerosis.

Genny Lubrini, Marcos Ríos Lago, Jose A Periañez, Antonio Tallón Barranco, Consuelo De Dios, Mireya Fernández-Fournier, Exuperio Diez Tejedor, Ana Frank García

Erratum issued Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04730466 (Validation of Cognitive Rehabilitation as a Balance Rehabilitation Strategy in Patients With Parkinson's Disease), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04730466 nacompletednot on this mapstarted 2021, after this paper: background citation

Validation of Cognitive Rehabilitation as a Balance Rehabilitation Strategy in Patients With Parkinson's Disease: Study Protocol for a Randomized Controlled Trial

TypeinterventionalSponsorUniversidad Francisco de VitoriaRan2021 to 2022Enrolled46ConditionsParkinson DiseaseArmsNeuropsychological rehabilitation
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Significance of the Diagnosis of Executive Functions in Patients with Relapsing-Remitting Multiple Sclerosis.International journal of environmental research and public health · 2021
    Article
  2. Dissociable cognitive patterns related to depression and anxiety in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Genny LubriniDepartment of Neurology, La Paz University Hospital, IdiPAZ Health Research Institute, Autónoma University of Madrid, Madrid, Spain genny.lubrini@hotmail.it.
Marcos Ríos LagoBrain Damage Service, Hospital Beata Maria Ana, Madrid, Spain; Department of Basic Psychology II, UNED, Madrid, Spain.
Jose A PeriañezDepartment of Basic Psychology II, Complutense University of Madrid, Madrid, Spain.
Antonio Tallón BarrancoDepartment of Neurology, La Paz University Hospital, IdiPAZ Health Research Institute, Autónoma University of Madrid, Madrid, Spain.
Consuelo De DiosDepartment of Psychiatry, La Paz University Hospital, IdiPAZ Health Research Institute, Autónoma University of Madrid, Madrid, Spain.
Mireya Fernández-FournierDepartment of Neurology, La Paz University Hospital, IdiPAZ Health Research Institute, Autónoma University of Madrid, Madrid, Spain.
Exuperio Diez TejedorDepartment of Neurology, La Paz University Hospital, IdiPAZ Health Research Institute, Autónoma University of Madrid, Madrid, Spain.
Ana Frank GarcíaDepartment of Neurology, La Paz University Hospital, IdiPAZ Health Research Institute, Autónoma University of Madrid, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSlowness of information processing has been suggested as a fundamental factor modulating cognitive impairment in multiple sclerosis (MS). However, the contribution of depressive symptoms (DS) to slowness remains unclear. One of the most accepted hypotheses on the impact of depression on the general population suggests that depression interferes only with tasks requiring high cognitive demands. However, no studies have investigated if the same pattern occurs in MS.

objectiveThe aim of this study was to determine the profile of the contribution of DS to slowness.

methodsFour Reaction Time (RT) tasks requiring an increasing level of cognitive demands were administered to 35 relapsing remitting MS patients with DS, 33 MS patients without DS, 17 depressed non-MS patients and 27 controls.

resultsMS patients without DS obtained longer RTs than controls in all the tasks. On the contrary, depressed non-MS patients were slower than controls only in the most demanding task. Finally, MS patients with DS were slower than MS patients without DS not only in the most demanding task but also in the task requiring a lower level of cognitive demands.

conclusionThe contribution of DS to slowness depends on the level of cognitive demands. However, its impact on MS is more deleterious than on the general population.

Indexed as

AdultCognitive DysfunctionDepressionFemaleHumansMaleMiddle AgedMultiple Sclerosis, Relapsing-RemittingPsychomotor PerformanceReaction TimeDepressioninformation processing speedmultiple sclerosisneuropsychological assessmentReaction Timevisual search

Identifiers

PMID27742916

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.