Evidence map›Paper›PMID 27742888›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [

Christine DeLorenzo, Jean-Dominique Gallezot, John Gardus, Jie Yang, Beata Planeta, Nabeel Nabulsi, R Todd Ogden, David C Labaree, Yiyun H Huang, J John Mann and 6 more

Abstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Dynamic alterations in the central glutamatergic status following food and glucose intake:Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Trial
  2. Trial
  3. Article
  4. Article
  5. Test-retest properties of [EJNMMI research · 2025
    Article
  6. Article
  7. Quantification of [Current neuropharmacology · 2025
    Article
  8. Dynamic neuroreceptor positron emission tomography in non-anesthetized rats using point source based motion correction: A feasibility study with [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  9. Article
  10. Article
  11. Testing PET-[Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. mGluRHuman brain mapping · 2022
    Article
  17. Article
  18. Relative Strengths of Three Linearizations of Receptor Availability: Saturation, Inhibition, and Occupancy Plots.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Christine DeLorenzo1 Department of Psychiatry, Stony Brook University, Stony Brook, USA.
Jean-Dominique Gallezot4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, USA.
John Gardus1 Department of Psychiatry, Stony Brook University, Stony Brook, USA.
Jie Yang5 Department of Preventive Medicine, Stony Brook University, Stony Brook, USA.
Beata Planeta4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, USA.
Nabeel Nabulsi4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, USA.
R Todd Ogden3 Department of Psychiatry, Columbia University, New York, USA.
David C Labaree4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, USA.
Yiyun H Huang4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, USA.
J John Mann3 Department of Psychiatry, Columbia University, New York, USA.
Fabrizio Gasparini6 Novartis Institutes for Biomedical Research, Basel, Switzerland.
Xin Lin3 Department of Psychiatry, Columbia University, New York, USA.
Jonathan A Javitch3 Department of Psychiatry, Columbia University, New York, USA.
Ramin V Parsey1 Department of Psychiatry, Stony Brook University, Stony Brook, USA.
Richard E Carson4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, USA.
Irina Esterlis4 Department of Radiology and Biomedical Imaging, Yale University, New Haven, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Structure of the Dopamine D2-Like Receptor Binding SitesR01MH054137 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI JAVITCH, JONATHAN A · 1995 to 2025
$12.0M
Molecular Determinants for the Action of PsychostimulantsK05DA022413 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JAVITCH, JONATHAN A · 2007 to 2016
$1.3M
Role of Beta2-nAChR in Bipolar DisorderK01MH092681 · NIMH · YALE UNIVERSITY · PI ESTERLIS, IRINA · 2011 to 2015
$850k
Characterization of a New Metabotropic Glutamate Receptor Subtype 5 PET LigandK01MH091354 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI DELORENZO, CHRISTINE · 2011 to 2014
$691k
NCATS NIH HHS UL1 TR001863NIDA NIH HHS K05 DA022413NIMH NIH HHS K01 MH091354NIMH NIH HHS K01 MH092681NIMH NIH HHS R01 MH054137
6 · The paper itself

Abstract

Positron emission tomography tracers [

Indexed as

NitrilesOximesPyridinesAdultBrainFemaleHealthy VolunteersHumansImage Processing, Computer-AssistedMaleMolecular ImagingPositron-Emission TomographyProtein BindingRadiopharmaceuticalsReceptor, Metabotropic Glutamate 5Reproducibility of Results3-(6-methylpyridin-2-ylethynyl)cyclohex-2-enone-O-methyloxime3-fluoro-5-((pyridin-3-yl)ethynyl)benzonitrileGRM5 protein, humanNitrilesOximesPyridinesRadiopharmaceuticalsReceptor, Metabotropic Glutamate 5[11C]ABP688[18F]FPEBmetabotropic glutamate receptor subtype 5Positron emission tomographytest–retest

Identifiers

PMID27742888
PMCPMC5536783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.