ArticleJournal of immunology (Baltimore, Md. : 1950)2016
Small Molecule Inhibition of Rab7 Impairs B Cell Class Switching and Plasma Cell Survival To Dampen the Autoantibody Response in Murine Lupus.
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In one paragraph
Article in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Geranylgeranylation is required for B-cell proliferation and plasma cell survival implications for autoimmune therapy.Cellular & molecular immunology · 2026Article
- Hepatic control of immunometabolism: implications for the pathogenesis, diagnosis and treatment of rheumatic diseases.Nature reviews. Rheumatology · 2026Review
- Integrative Proteomic and Phosphoproteomic Analysis Reveals Altered Vesicle Transport in Systemic Lupus Erythematosus.Clinical proteomics · 2026Article
- Cell-nanoplastics association impacts cell proliferation and motility.bioRxiv : the preprint server for biology · 2026Article
- Endosome traffic in rheumatic diseases: mechanistic insights and therapeutic opportunities.Nature reviews. Rheumatology · 2026Review
- Immune targeting of triple-negative breast cancer through a clinically actionable STING agonist-CAR T cell platform.Cell reports. Medicine · 2025Article
- Rab7 inhibitor enhances stem cell differentiation into keratinocyte-like cells with anti-inflammatory properties.Frontiers in immunology · 2025Article
- Targeting RAB7 in human B lymphoma by a small molecule inhibitor arrests tumor cell growth.Frontiers in oncology · 2025Article
- From promise to practice: evaluating the clinical impact of FcRn inhibition in IgG-mediated autoimmune rheumatic diseases.Frontiers in immunology · 2025Review
- Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis.eLife · 2024Article
- FOXO3/Rab7-Mediated Lipophagy and Its Role in Zn-Induced Lipid Metabolism in Yellow Catfish (Genes · 2024Article
- Article
- Intrathecal Injection of Mesenchymal Stromal Cell Cultured on 3D Fiber Ameliorates Multiple Organ Damage in Murine Lupus.Stem cells translational medicine · 2022Article
- Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer's Disease.Biomedicines · 2022Review
- Rab GTPases in the differential processing of phagocytosed pathogens versus efferocytosed apoptotic cells.Histology and histopathology · 2021Review
- Article
- B Cell Endosomal RAB7 Promotes TRAF6 K63 Polyubiquitination and NF-κB Activation for Antibody Class-Switching.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids.Nature communications · 2020Article
- CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke.Acta pharmacologica Sinica · 2019Article
- Rab7b Overexpression-Ameliorated Ischemic Brain Damage Following tMCAO Involves Suppression of TLR4 and NF-κB p65.Journal of molecular neuroscience : MN · 2019Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Tonika LamDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; and.ORCID 0000-0002-6270-7234
Dennis V KulpDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; and.ORCID 0000-0002-9048-7048
Rui WangDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; and.
Zheng LouDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; and.
Julia TaylorDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; and.ORCID 0000-0002-7549-0812
Carlos E RiveraDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; and.
Hui YanDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; and.
Qi ZhangDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; and.
Zhonghua WangDepartment of Biochemistry, University of Texas School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.ORCID 0000-0001-6906-107X
Hong ZanDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; and.
Dmitri N IvanovDepartment of Biochemistry, University of Texas School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
Guangming ZhongDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; and.ORCID 0000-0001-7053-5009
Paolo CasaliDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; and pcasali@uthscsa.edu xuz3@uthscsa.edu.ORCID 0000-0002-8982-5177
Zhenming XuDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229; and pcasali@uthscsa.edu xuz3@uthscsa.edu.
The University of Texas Health Science Center at San Antonio · US
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1MMECHANISMS OF CHLAMYDIAL EVASION OF IMMUNE RECOGNATIONR01AI047997 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2000 to 2021
$6.9MIntrinsic B cell epigenetic regulation of antibody and autoantibody responses by Sirt1R01AI105813 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CASALI, PAOLO · 2014 to 2023
$4.5MSomatic hypermutation and class switching in autoimmunityR01AI079705 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CASALI, PAOLO · 2010 to 2019
$4.1MImmunoglobulin class switch DNA recombinationR01AI045011 · NIAID · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI CASALI, PAOLO · 2000 to 2011
$3.8MRetroviral capsid recognition by TRIM5alpha restriction factorsR01AI104476 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI IVANOV, DMITRI N · 2014 to 2018
$1.8MRab7 and NF-kappaB in B cell activation and dysregulationR21AI124172 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, ZHENMING · 2016 to 2017
$413kMolecular mechanisms in the generation of autoantibodies and lupusR56AI079705 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CASALI, PAOLO · 2008 to 2008
$381kEpigenetic downregulation of the antibody response and inhibition of autoimmunityR56AI105813 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI CASALI, PAOLO · 2013 to 2013
$286kNCI NIH HHS P30 CA054174NIAID NIH HHS R01 AI045011NIAID NIH HHS R01 AI047997NIAID NIH HHS R01 AI079705NIAID NIH HHS R01 AI104476NIAID NIH HHS R01 AI105813NIAID NIH HHS R21 AI124172NIAID NIH HHS R56 AI079705NIAID NIH HHS R56 AI105813
Abstract
IgG autoantibodies mediate pathology in systemic lupus patients and lupus-prone mice. In this study, we showed that the class-switched IgG autoantibody response in MRL/Fas
Indexed as
AnimalsAutoantibodiesB-LymphocytesCell ProliferationCell SurvivalChlamydia InfectionsFemaleGene Expression RegulationHeterocyclic Compounds, 2-RingImmunoglobulin Class SwitchingImmunoglobulin GLupus Erythematosus, SystemicLymphocyte ActivationMiceMice, Inbred MRL lprNF-kappa BAutoantibodiesCID1067700Heterocyclic Compounds, 2-RingImmunoglobulin GNF-kappa Brab7 GTP-Binding Proteinsrab7 GTP-binding proteins, humanrab7 GTP-binding proteins, mouserab GTP-Binding ProteinsThiourea
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.