ArticleCancer research2016
Body Mass Index, Waist Circumference, Diabetes, and Risk of Liver Cancer for U.S. Adults.
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Article in Cancer research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 7 of them syntheses that pooled it.
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93citing papers in PubMed, 7 pooled it
11.0field-weighted citation impact, top 1% of its field
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Who cites it
93 citing papers in PubMed, 7 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- Association between metabolic risk factors and hepatocellular carcinoma: a systematic review and meta-analysis of cohort studies.Frontiers in medicine · 2026Pooled it
- Oral contraceptive use and risk of liver cancer: a population-based study, systematic review, and meta-analysis.The Lancet. Oncology · 2025Pooled it
- Pooled it
- Abdominal obesity and digestive system cancer: a systematic review and meta-analysis of prospective studies.BMC public health · 2023Pooled it
- Obesity and the risk of primary liver cancer: A systematic review and meta-analysis.Clinical and molecular hepatology · 2021Pooled it
- Body Mass Index, Diabetes and Intrahepatic Cholangiocarcinoma Risk: The Liver Cancer Pooling Project and Meta-analysis.The American journal of gastroenterology · 2018Pooled it
- Pooled it
- High Prevalence of Undiagnosed Hyperglycemia in Low-Income Overweight and Obese Hispanic Women in Oregon.Journal of racial and ethnic health disparities · 2019Trial
- Obesity Promotes Lung Carcinogenesis Through Airway Immune Dysfunction.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026Article
- Hepatocellular Carcinoma Survival in People With and Without HIV in the United States, 2001-2019.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Article
- Artificially Sweetened and Sugar-Sweetened Beverage Intake and Risk of Liver Cancer.JAMA network open · 2026Article
- Large cohort studies assessing sex-specific associations between anthropometric indices and liver cancer death.JHEP reports : innovation in hepatology · 2026Article
- Trajectory Modelling of Prognostic Biomarkers Linked to Liver Cancer Risk: A Systematic Review.Liver cancer · 2026Article
- Pre-diagnostic immunological markers of bacterial translocation and liver cancer risk: A nested case-control analysis of 12 prospective cohorts.International journal of cancer · 2026Article
- Global liver cancer burden attributed to high body mass index: trends, projections, and its relationship with socioeconomic development status (1990-2021).European journal of gastroenterology & hepatology · 2026Article
- Pre-diagnostic circulating bile acid concentrations and liver cancer risk: a nested case-control analysis of 12 cohorts.JNCI cancer spectrum · 2025Article
- Circulating per- and polyfluoroalkyl substances and liver cancer risk: a nested case-control analysis of individual participant data from 12 prospective cohorts.Environmental health perspectives · 2025Article
- Pharmacological Dissection Identifies Retatrutide Overcomes the Therapeutic Barrier of Obese TNBC Treatments through Suppressing the Interplay between Glycosylation and Ubiquitylation of YAP.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- CK19 protein expression: the best cutoff value on the prognosis and the prognosis model of hepatocellular carcinoma.BMC cancer · 2025Article
- Global, regional, and national burden of liver cancer attributable to high BMI, 1990-2021, with future projections to 2040.Frontiers in oncology · 2025Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 1 institution in 1 country.
Peter T CampbellEpidemiology Research Program, American Cancer Society, Atlanta, Georgia. peter.campbell@cancer.org.
Christina C NewtonEpidemiology Research Program, American Cancer Society, Atlanta, Georgia.
Neal D FreedmanDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Jill KoshiolDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Michael C AlavanjaDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Laura E Beane FreemanDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Julie E BuringDepartment of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts.
Andrew T ChanDepartment of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Dawn Q ChongDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Division of Medical Oncology, National Cancer Centre Singapore, Singapore.
Mridul DattaDepartment of Nutrition Science, Purdue University, West Lafayette, Indiana.
Mia M GaudetEpidemiology Research Program, American Cancer Society, Atlanta, Georgia.
J Michael GazianoDepartment of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. VA Boston Healthcare System, Boston, Massachusetts.
Edward L GiovannucciDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts. Department of Nutrition, Harvard TH Chan School of Public Health, Boston, Massachusetts.
Barry I GraubardDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Albert R HollenbeckAARP, Washington, DC (retired).
Lindsey KingDepartment of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
I-Min LeeDepartment of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts.
Martha S LinetDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Julie R PalmerSlone Epidemiology Center at Boston University, Boston, Massachusetts.
Jessica L PetrickDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Jenny N PoynterDivision of Pediatric Epidemiology and Clinical Research and Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Mark P PurdueDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Kim RobienDepartment of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC.
Lynn RosenbergSlone Epidemiology Center at Boston University, Boston, Massachusetts.
Vikrant V SahasrabuddheDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Catherine SchairerDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Howard D SessoDepartment of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts.
Alice J SigurdsonDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Victoria L StevensEpidemiology Research Program, American Cancer Society, Atlanta, Georgia.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University at Buffalo, Buffalo, New York.
Anne Zeleniuch-JacquotteDepartment of Population Health, New York University School of Medicine, New York, New York.
Andrew G RenehanFaculty Institute of Cancer Sciences, University of Manchester, Manchester, United Kingdom.
Katherine A McGlynnDivision of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland.
Brigham and Women's Hospital · US
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8MStudies of Occupational Cancer (Pesticides)ZIACP010119 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI BEANE FREEMAN, LAURA · 2009 to 2025
$46.1MValidity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MRESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COSTA, MAX · 1985 to 2020
$26.1MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MFOLLOW-UP STUDY FOR CAUSES OF ILLNESS IN BLACK WOMENR01CA058420 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 1999 to 2013
$20.7MPhysicians' Health Study II: Prevention Trial of VitaminsR01CA097193 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI GAZIANO, J. MICHAEL · 2002 to 2011
$15.7MA Follow-up Study for Causes of Cancer in Black WomenUM1CA164974 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 2012 to 2017
$13.7MCancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5MBIOCHEMICAL MARKERS IN THE NURSES'HEALTH STUDY COHORTR01CA049449 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HANKINSON, SUSAN E · 1989 to 2008
$11.3MIntramural NIH HHS Z01 CP010119Intramural NIH HHS Z01 ES049030NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA034944NCI NIH HHS R01 CA039742NCI NIH HHS R01 CA040360NCI NIH HHS R01 CA047988NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA058420NCI NIH HHS R01 CA097193NCI NIH HHS R01 CA098661NCI NIH HHS UM1 CA164974NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA182913NCI NIH HHS UM1 CA186107NHLBI NIH HHS R01 HL026490NHLBI NIH HHS R01 HL034595NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL080467NIEHS NIH HHS P30 ES000260
Abstract
Incidence rates for liver cancer have increased 3-fold since the mid-1970s in the United States in parallel with increasing trends for obesity and type II diabetes mellitus. We conducted an analysis of baseline body mass index (BMI), waist circumference (WC), and type II diabetes mellitus with risk of liver cancer. The Liver Cancer Pooling Project maintains harmonized data from 1.57 million adults enrolled in 14 U.S.-based prospective studies. Cox regression estimated HRs and 95% confidence intervals (CI) adjusted for age, sex, study center, alcohol, smoking, race, and BMI (for WC and type II diabetes mellitus). Stratified analyses assessed whether the BMI-liver cancer associations differed by hepatitis sera-positivity in nested analyses for a subset of cases (n = 220) and controls (n = 547). After enrollment, 2,162 incident liver cancer diagnoses were identified. BMI, per 5 kg/m
Indexed as
Body Mass IndexWaist CircumferenceAdultAgedDiabetes Mellitus, Type 2FemaleHumansLiver NeoplasmsMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk Factors
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