ArticleBiology open2016
Heterotypic interactions regulate cell shape and density during color pattern formation in zebrafish.
Article in Biology open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Studies of Turing pattern formation in zebrafish skin.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2021Review
- Pigment pattern morphospace of Danio fishes: evolutionary diversification and mutational effects.Biology open · 2021Article
- Immunoglobulin superfamily receptor Junctional adhesion molecule 3 (Jam3) requirement for melanophore survival and patterning during formation of zebrafish stripes.Developmental biology · 2021Article
- A complex genetic architecture in zebrafish relatives Danio quagga and D. kyathit underlies development of stripes and spots.PLoS genetics · 2021Article
- Role of the Connexin C-terminus in skin pattern formation of Zebrafish.BBA advances · 2021Article
- In situ differentiation of iridophore crystallotypes underlies zebrafish stripe patterning.Nature communications · 2020Article
- Evolution of the potassium channel gene Kcnj13 underlies colour pattern diversification in Danio fish.Nature communications · 2020Article
- Genome mapping of aProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Topological data analysis of zebrafish patterns.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Galanin Signaling in the Brain Regulates Color Pattern Formation in Zebrafish.Current biology : CB · 2020Article
- The identification of genes involved in the evolution of color patterns in fish.Current opinion in genetics & development · 2019Review
- Genetic mechanism underlying sexual plasticity and its association with colour patterning in zebrafish (Danio rerio).BMC genomics · 2019Article
- A curated gene list for expanding the horizons of pigmentation biology.Pigment cell & melanoma research · 2019Review
- Periodic patterns in Rodentia: Development and evolution.Experimental dermatology · 2019Article
- Iridophores as a source of robustness in zebrafish stripes and variability in Danio patterns.Nature communications · 2018Article
- Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2.Developmental cell · 2018Article
- Self-organizing spots get under your skin.PLoS biology · 2017Review
- Gain-of-function mutations in Aqp3a influence zebrafish pigment pattern formation through the tissue environment.Development (Cambridge, England) · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The conspicuous striped coloration of zebrafish is produced by cell-cell interactions among three different types of chromatophores: black melanophores, orange/yellow xanthophores and silvery/blue iridophores. During color pattern formation xanthophores undergo dramatic cell shape transitions and acquire different densities, leading to compact and orange xanthophores at high density in the light stripes, and stellate, faintly pigmented xanthophores at low density in the dark stripes. Here, we investigate the mechanistic basis of these cell behaviors in vivo, and show that local, heterotypic interactions with dense iridophores regulate xanthophore cell shape transition and density. Genetic analysis reveals a cell-autonomous requirement of gap junctions composed of Cx41.8 and Cx39.4 in xanthophores for their iridophore-dependent cell shape transition and increase in density in light-stripe regions. Initial melanophore-xanthophore interactions are independent of these gap junctions; however, subsequently they are also required to induce the acquisition of stellate shapes in xanthophores of the dark stripes. In summary, we conclude that, whereas homotypic interactions regulate xanthophore coverage in the skin, their cell shape transitions and density is regulated by gap junction-mediated, heterotypic interactions with iridophores and melanophores.
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