Evidence map›Paper›PMID 27742574›Full record

Trial reportBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation2017

Pretransplantation Exercise and Hematopoietic Cell Transplantation Survival: A Secondary Analysis of Blood and Marrow Transplant Clinical Trials Network (BMT CTN 0902).

John R Wingard, William A Wood, Michael Martens, Jennifer Le-Rademacher, Brent Logan, Jennifer M Knight, Paul B Jacobsen, Heather Jim, Navneet S Majhail, Karen Syrjala and 2 more

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06953648 (Remotely Monitored, Mobile Health-supported, High Intensity Interval Training Before Hematopoietic Stem Cell Transplantation), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06953648 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Remotely Monitored, Mobile Health-supported, High Intensity Interval Training Before Hematopoietic Stem Cell Transplantation (REMM-HIIT-HCT)

TypeinterventionalSponsorUniversity of Kansas Medical CenterRan2025 to 2030Enrolled126ConditionsHematopoietic Stem Cell Transplantation, Cardiorespiratory FitnessArmsHigh Intensity Interval Training
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. A hospital and home-based exercise program to address functional decline in people following allogeneic stem cell transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

John R WingardUniversity of Florida, Gainesville, Florida. Electronic address: wingajr@ufl.edu.
William A WoodLineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina.
Michael MartensCenter for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.
Jennifer Le-RademacherMayo Clinic, Rochester, Minnesota.
Brent LoganCenter for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.
Jennifer M KnightCenter for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.
Paul B JacobsenH. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Heather JimH. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Navneet S MajhailTaussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.
Karen SyrjalaFred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington.
J Douglas RizzoCenter for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.
Stephanie J LeeFred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington.

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Data Resource for Analyzing Blood &Marrow TransplantsU24CA076518 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI Amy M Moskop, Bronwen Shaw · 1998 to 2026
$105.2M
Easy-to-read Informed Consent for HCT Clinical TrialsU10HL069294 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI HOROWITZ, MARY MARESCA · 2011 to 2016
$43.8M
Internet Studies to Enhance Long Term Survivorship after Hematologic MalignancyR01CA160684 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SYRJALA, KAREN LESLIE · 2011 to 2015
$3.4M
Core Clinical Consortium for Blood and Marrow Transplant Clinical Trials NetworkUG1HL069301 · NHLBI · UNIVERSITY OF FLORIDA · PI HSU, JACK W · 2017 to 2023
$1.1M
Blood & Marrow Clinical Trials Network - Hutchinson Center Core Clinical SitU10HL069246 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI APPELBAUM, FREDERICK · 2011 to 2016
$1.1M
Sargrastim and Plerixafor vs. Filgrastim for Allogeneic Stem Cell MobilizationU10HL109137 · NHLBI · WASHINGTON UNIVERSITY · PI WESTERVELT, PETER · 2011 to 2016
$937k
Core Clinical Consortium for Blood and Marrow Transplant Clinical Trials NetworkU10HL069301 · NHLBI · UNIVERSITY OF FLORIDA · PI WINGARD, JOHN R. · 2011 to 2016
$882k
NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA160684NCI NIH HHS U24 CA076518NHLBI NIH HHS U10 HL069246NHLBI NIH HHS U10 HL069294NHLBI NIH HHS U10 HL069301NHLBI NIH HHS U10 HL109137NHLBI NIH HHS UG1 HL069301
6 · The paper itself

Abstract

Blood and Marrow Transplant Clinical Trials Network (BMT CTN) protocol 0902 evaluated whether exercise and stress management training before hematopoietic cell transplantation (HCT) improved physical and mental functioning after HCT. Neither overall survival nor other patient-reported transplantation outcomes were improved by the training intervention. In some animal studies of HCT, moderate-intensity exercise for 8 weeks before HCT has been associated with positive effects on hematopoietic progenitors, resulting in improved donor engraftment and improved survival. Accordingly, we performed a secondary analysis of data from BMT CTN 0902 to determine whether exercise engagement before HCT was associated with engraftment and survival. We found no significant associations between self-reported pre-HCT exercise levels and engraftment or survival. There was also no effect of pretransplantation exercise on either neutrophil or platelet engraftment. These findings do not support the observations in animal models but are limited by several shortcomings that do not refute the hypothesis that exercise before HCT may be beneficial.

Indexed as

ExerciseGraft SurvivalSurvivalAdultAgedBlood PlateletsHematopoietic Stem Cell TransplantationHumansMiddle AgedNeutrophilsPatient Reported Outcome MeasuresSelf ReportYoung AdultAllogeneicExerciseHematopoieticTransplantation

Identifiers

PMID27742574
PMCPMC5182134

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.