ArticleExperimental eye research2016
Complete metabolome and lipidome analysis reveals novel biomarkers in the human diabetic corneal stroma.
Article in Experimental eye research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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Who cites it
37 citing papers in PubMed, 59 citations in OpenAlex.
- Metabolites and proteins may mediate the relationship between diet quality and insulin sensitivity in young adult cohort.Journal of diabetes and metabolic disorders · 2026Article
- Safety and efficacy of keratorefractive surgery in diabetes mellitus: A clinical review.World journal of clinical cases · 2026Review
- Diabetic keratopathy and nuclear proteins (Review).Molecular medicine reports · 2026Review
- Tear proteomics reveals expressed proteins and potential pathways associated with diabetic keratopathy.Eye (London, England) · 2025Article
- Fabrication of a 3D Corneal Model Using Collagen Bioink and Human Corneal Stromal Cells.Journal of functional biomaterials · 2025Article
- Corneal stromal microdots accumulation and its association with corneal neurodegeneration and retinal microvascular perfusion in diabetes.Frontiers in endocrinology · 2025Article
- Integrated oral microbiome and metabolome analysis unveils key biomarkers and functional pathway alterations in patients with acute myocardial infarction.Frontiers in cellular and infection microbiology · 2025Article
- Immune-Mediated Ocular Surface Disease in Diabetes Mellitus-Clinical Perspectives and Treatment: A Narrative Review.Biomedicines · 2024Review
- An untargeted metabolomics approach to study changes of the medium during human cornea culture.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Effects of hypoxia in the diabetic corneal stroma microenvironment.Experimental eye research · 2024Article
- Characterizing the metabolic divide: distinctive metabolites differentiating CAD-T2DM from CAD patients.Cardiovascular diabetology · 2024Article
- Differential lipid signaling from CD4Frontiers in immunology · 2024Article
- Skewing cPLAScience signaling · 2023Article
- Review
- The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas.Progress in retinal and eye research · 2022Review
- Why Do High-Risk Patients Develop or Not Develop Coronary Artery Disease? Metabolic Insights from the CAPIRE Study.Metabolites · 2022Article
- Monocarboxylate Transporters: Role and Regulation in Corneal Diabetes.Analytical cellular pathology (Amsterdam) · 2022Article
- Potential underlying genetic associations between keratoconus and diabetes mellitus.Advances in ophthalmology practice and research · 2021Article
- Molecular characteristics and spatial distribution of adult human corneal cell subtypes.Scientific reports · 2021Article
- Nerve influence on the metabolism of type I and type II diabetic corneal stroma: an in vitro study.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Prolonged hyperglycemia during diabetes mellitus can cause severe ophthalmic complications affecting both the anterior and posterior ocular segments leading to impaired vision or blindness. Diabetes-induced corneal pathologies are associated with decreased wound healing capacity, corneal edema, and altered epithelial basement membrane. The mechanism by which diabetes modulates structure and function within the corneal stroma are unknown. In our study, we characterized the effects of diabetes on extracellular matrix, lipid transport, and cellular metabolism by defining the entire metabolome and lipidome of Type 1 and Type 2 human diabetic corneal stroma. Significant increases in Collagen I and III were found in diabetic corneas suggesting that diabetes promotes defects in matrix structure leading to scarring. Furthermore, increased lipid content, including sphingosine-1-phosphate and dihydrosphingosine, in diabetic corneas compared to healthy controls were measured suggesting altered lipid retention. Metabolomics analysis identified elevated tryptophan metabolites, independent of glucose metabolism, which correlated with upregulation of the Kynurenine pathway in diabetic corneas. We also found significant upregulation of novel biomarkers aminoadipic acid, D,L-pipecolic acid, and dihydroorotate. Our study links aberrant tryptophan metabolism to end-stage pathologies associated with diabetes indicating the potential of the Kynurenine pathway as a therapeutic target for inhibiting diabetes-associated defects in the eye.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.