ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2017
Impact of Right Ventricular Dysfunction and Tricuspid Regurgitation on Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement.
Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07623083 (Evaluation of a Treatment Algorithm for the Management of TAVI Patients With Significant Concomitant Mitral or Tricuspid Regurgitation), which is not on this map. Cited by 47 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of a Treatment Algorithm for the Management of TAVI Patients With Significant Concomitant Mitral or Tricuspid Regurgitation
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Tricuspid Regurgitation and Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis.Arquivos brasileiros de cardiologia · 2023Pooled it
- Prognostic Assessment of Right Ventricular Systolic Dysfunction on Post-Transcatheter Aortic Valve Replacement Short-Term Outcomes: Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2020Pooled it
- Impact of tricuspid regurgitation and right ventricular dysfunction on outcomes after transcatheter aortic valve replacement: A systematic review and meta-analysis.Clinical cardiology · 2019Pooled it
- Staging classification of aortic stenosis based on the extent of cardiac damage.European heart journal · 2017Trial
- Right ventricular-pulmonary artery uncoupling identifies higher risk of combined pulmonary hypertension in patients undergoing TAVR.Cardiovascular ultrasound · 2026Article
- Prognostic Impact of Residual Renal Congestion at Discharge After Transcatheter Aortic Valve Implantation.CJC open · 2026Article
- Prognostic value of liver shear wave elastography after transcatheter aortic valve implantation in severe aortic stenosis.International journal of cardiology. Heart & vasculature · 2026Article
- Deep learning enables fully automated cineCT-based assessment of regional right ventricular function.European heart journal. Imaging methods and practice · 2026Article
- Beyond the left ventricle: modern echocardiographic assessment of right ventricular function in tricuspid regurgitation.Cardiovascular ultrasound · 2025Review
- Prognostic impact of right ventricular dysfunction in patients with severe aortic stenosis treated with trans-catheter aortic valve implantation.Internal and emergency medicine · 2025Article
- Natural History of Tricuspid Regurgitation After Transcatheter Aortic Valve Implantation.Journal of the American Heart Association · 2025Observational
- One-Year Outcome of Patients Undergoing Transcatheter Aortic Valve Replacement with Concomitant SignificantTricuspid Regurgitation.Journal of cardiovascular development and disease · 2025Article
- Right ventricular to pulmonary artery coupling in patients with different types of aortic stenosis undergoing TAVI.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Impact of Right Heart Failure on Outcomes of Transcatheter Aortic Valve Implantation: Insights from the National Inpatient Sample.Journal of clinical medicine · 2025Article
- Prognostic Value of the Tricuspid Regurgitation Impact on Outcomes (TRIO) Score in Patients Undergoing Transcatheter Aortic Valve Implantation.Reviews in cardiovascular medicine · 2025Article
- The right heart perspective in chronic cardiorenal syndrome: the key role of right heart function and tricuspid regurgitation innovation.Frontiers in cardiovascular medicine · 2025Review
- Human epididymis protein 4 is a useful predictor of post-operative prognosis in patients with severe aortic stenosis.ESC heart failure · 2024Article
- Multiple Valvular Heart Disease in the Transcatheter Era: A State-of-the-Art Review.Structural heart : the journal of the Heart Team · 2024Review
- Tricuspid Regurgitation and TAVR: Outcomes, Risk Factors and Biomarkers.Journal of clinical medicine · 2024Article
- Severe Aortic Stenosis Associated with Other Valve Diseases: Open Surgery or Percutaneous Treatment?Reviews in cardiovascular medicine · 2024Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRight ventricular (RV) dysfunction and tricuspid regurgitation (TR) may coexist with aortic stenosis. The aim of this study was to assess the association between RV dysfunction, TR, associated comorbidities, and outcomes following transcatheter aortic valve replacement (TAVR).
methodsA retrospective analysis was conducted of baseline and 6-month clinical and echocardiographic parameters, including TR grade, RV size (grade, end-diastolic and end-systolic areas, annular diameter), and function (grade, tricuspid annular plane systolic excursion [TAPSE], fractional area change, Tei index), in 519 consecutive TAVR patients.
resultsThe prevalence of moderate or greater TR was 11% (n = 59). Although TR was associated with increased mortality (P = .02) in unadjusted analysis, it did not demonstrate an independent association with outcome when adjusted for RV dysfunction (TAPSE; P = .30) or multiple clinical parameters (P ≥ .20). RV parameters associated with poor outcomes included TAPSE (P = .006) and Tei index (P = .005). TAPSE was associated with lower survival even when adjusted for TR (P = .009) and all clinical parameters (P = .01). Persistence of moderate or greater TR 6 months after TAVR seemed to be associated with lower survival (P = .02), even when adjusted for clinical and RV parameters (P = .07).
conclusionsTR in association with aortic stenosis is frequently progressive despite TAVR but is not independently associated with outcomes. RV function is a stronger driver of adverse outcomes compared with TR itself, and RV quantitative rather than qualitative evaluation is the key to stratify these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.