Evidence map›Paper›PMID 27742110›Full record

ReviewMagnetic resonance imaging clinics of North America2016

Interrogating Metabolism in Brain Cancer.

Travis C Salzillo, Jingzhe Hu, Linda Nguyen, Nicholas Whiting, Jaehyuk Lee, Joseph Weygand, Prasanta Dutta, Shivanand Pudakalakatti, Niki Zacharias Millward, Seth T Gammon and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Magnetic resonance imaging clinics of North America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Travis C SalzilloDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA; The University of Texas Health Science Center at Houston, Houston, TX, USA.
Jingzhe HuDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA; Department of Bioengineering, Rice University, Houston, TX, USA.
Linda NguyenThe University of Texas Health Science Center at Houston, Houston, TX, USA.
Nicholas WhitingDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.
Jaehyuk LeeDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.
Joseph WeygandDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA; The University of Texas Health Science Center at Houston, Houston, TX, USA.
Prasanta DuttaDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.
Shivanand PudakalakattiDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.
Niki Zacharias MillwardDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.
Seth T GammonDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.
Frederick F LangDepartment of Neurosurgery, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.
Amy B HeimbergerDepartment of Neurosurgery, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.
Pratip K BhattacharyaDepartment of Cancer Systems Imaging, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA; The University of Texas Health Science Center at Houston, Houston, TX, USA. Electronic address: PKBhattacharya@mdanderson.org.

Funding

Tropism Enhanced Oncolytic Adenovirus for the Treatment of Brain TumorsP50CA127001 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Juan Fueyo · 2008 to 2026
$41.2M
Ultra-fast 15N Imaging in Choline in CancerR01CA122513 · NCI · HUNTINGTON MEDICAL RESEARCH INSTITUTES · PI ROSS, BRIAN DAVID · 2007 to 2011
$1.0M
(PQC5)Early Detection Pancreatic Cancer by Hyperpolarized Silicon NanoparticlesR21CA185536 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BHATTACHARYA, PRATIP K. · 2014 to 2015
$383k
PASADENA: Ultra-fast Carbon 13 Imaging for Early Diagnosis of CancerR21CA118509 · NCI · HUNTINGTON MEDICAL RESEARCH INSTITUTES · PI BHATTACHARYA, PRATIP K · 2006 to 2007
$298k
NCI NIH HHS P50 CA127001NCI NIH HHS R01 CA122513NCI NIH HHS R21 CA118509NCI NIH HHS R21 CA185536
6 · The paper itself

Abstract

This article reviews existing and emerging techniques of interrogating metabolism in brain cancer from well-established proton magnetic resonance spectroscopy to the promising hyperpolarized metabolic imaging and chemical exchange saturation transfer and emerging techniques of imaging inflammation. Some of these techniques are at an early stage of development and clinical trials are in progress in patients to establish the clinical efficacy. It is likely that in vivo metabolomics and metabolic imaging is the next frontier in brain cancer diagnosis and assessing therapeutic efficacy; with the combined knowledge of genomics and proteomics a complete understanding of tumorigenesis in brain might be achieved.

Indexed as

BrainBrain NeoplasmsHumansMagnetic Resonance SpectroscopyCESTDNPGC/MSHyperpolarizationMetabolic imagingMRIMRSNMR

Identifiers

PMID27742110
PMCPMC5091807

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.