Evidence map›Paper›PMID 27741979›Full record

ReviewGlobal heart2016

Biomarkers of Key Biological Pathways in CVD.

Nancy Swords Jenny, Nels C Olson, Matthew A Allison, Dena E Rifkin, Lori B Daniels, Ian H de Boer, Christina L Wassel, Russell P Tracy

Abstract readReview
In one paragraph

Review in Global heart, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Observational
4 · The record

Corrections and comments

  • Commented on by
    2016
5 · Who and what money

Authors and funding

8 authors.

Nancy Swords JennyDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA. Electronic address: Nancy.Jenny@med.uvm.edu.
Nels C OlsonDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
Matthew A AllisonDepartment of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA.
Dena E RifkinDepartment of Family and Preventive Medicine, University of California San Diego, La Jolla, CA, USA.
Lori B DanielsDepartment of Medicine, Division of Cardiovascular Medicine, University of California, San Diego, CA, USA.
Ian H de BoerKidney Research Institute, University of Washington, Seattle, WA, USA.
Christina L WasselDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA.
Russell P TracyDepartment of Pathology and Laboratory Medicine, University of Vermont College of Medicine, Burlington, VT, USA; Department of Biochemistry, University of Vermont College of Medicine, Burlington, VT, USA.

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
Phosphorus and Vitamin D Metabolism and Cardiovascular Outcomes: The multi-ethniR01HL096875 · NHLBI · UNIVERSITY OF WASHINGTON · PI DE BOER, IAN H, KESTENBAUM, BRYAN R · 2010 to 2019
$5.2M
Regional Dysfunction by MRI in Incident Heart FailureR01HL066075 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI LIMA, JOAO A C · 2001 to 2009
$4.0M
Multi-Scale Biology of Atherosclerosis in the Cellular Adhesion PathwayR01HL098077 · NHLBI · MAYO CLINIC ROCHESTER · PI BIELINSKI, SUZETTE JANINE · 2010 to 2014
$2.8M
Abdominal Body Composition, Inflammation and Cardiovascular DiseaaseR01HL088451 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALLISON, MATTHEW A · 2007 to 2011
$2.5M
Socioeconimic Patterning of Inflammation and HemostasisR01HL076831 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIEZ-ROUX, ANA V. · 2004 to 2007
$2.5M
Endothelial Dysfunction and the RV in the Multi-Ethnic Study of AtherosclerosisR01HL086719 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2007 to 2010
$2.0M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
Subclinical Renal Artery Atherosclerosis, Kidney Function and HypertensionR01DK080015 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALLISON, MATTHEW A · 2009 to 2011
$1.4M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NHLBI NIH HHS F32 HL010161NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL066075NHLBI NIH HHS R01 HL074338NHLBI NIH HHS R01 HL074406NHLBI NIH HHS R01 HL076831NHLBI NIH HHS R01 HL077449NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL086719NHLBI NIH HHS R01 HL088451NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL096875NHLBI NIH HHS R01 HL098077NHLBI NIH HHS R21 HL091217NHLBI NIH HHS R21 HL109924NHLBI NIH HHS RC1 HL100543NIDA NIH HHS R21 DA024273NIDDK NIH HHS K23 DK091521NIDDK NIH HHS R01 DK080015
6 · The paper itself

Abstract

This review provides background on the laboratory design for MESA (Multi-Ethnic Study of Atherosclerosis) as well as the approach used in MESA to select biomarkers for measurement. The research related to the multitude of circulating and urinary biomarkers of inflammation and other novel and emerging biological pathways in MESA is summarized by domain, or pathway, represented by the biomarker. The contributions of MESA biomarkers to our knowledge of these key pathways in the development and progression of atherosclerosis, cardiovascular disease, diabetes, kidney disease, and pulmonary disease are highlighted, as are the contributions of MESA to recommendations for clinical use of several of these biomarkers. In addition, contributions of MESA to multicohort genomics consortia and current collaborations in transomics and metabolomics are noted.

Indexed as

Acute Kidney InjuryAdipokinesAlgorithmsAtherosclerosisBiomarkersCardiovascular DiseasesChronic DiseaseEndothelium, VascularFatty AcidsFibrinolysisGonadal Steroid HormonesHomeostasisHumansInfectionsInsulin ResistanceLipid MetabolismAdipokinesBiomarkersFatty AcidsGonadal Steroid HormonesMineralsNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Troponin TVitamins

Identifiers

PMID27741979
PMCPMC5108521

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.