Evidence map›Paper›PMID 27741975›Full record

ReviewGlobal heart2016

Providing Evidence for Subclinical CVD in Risk Assessment.

Michael J Blaha, Joseph Yeboah, Mahmoud Al Rifai, Kiang Liu, Richard Kronmal, Philip Greenland

Open access · hybridAbstract readReview
In one paragraph

Review in Global heart, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Coronary Artery Calcium Scoring in Asymptomatic Patients.HCA healthcare journal of medicine · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Observational
  17. Detection of coronary calcifications with dual energy chest X-rays: clinical evaluation.The international journal of cardiovascular imaging · 2021
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Michael J BlahaJohns Hopkins Ciccarone Center for Prevention of Heart Disease, Baltimore, MD, USA. Electronic address: mblaha1@jhmi.edu.
Joseph YeboahDepartment of Internal Medicine/Cardiology, Wake Forest University Health Sciences, Winston Salem, NC, USA.
Mahmoud Al RifaiDepartments of Preventive Medicine and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Kiang LiuDepartments of Preventive Medicine and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Richard KronmalDepartment of Biostatistics, University of Washington School of Public Health, Seattle, WA, USA.
Philip GreenlandDepartments of Preventive Medicine and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Northwestern University · USUniversity of Washington · USWake Forest University · US

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
Phosphorus and Vitamin D Metabolism and Cardiovascular Outcomes: The multi-ethniR01HL096875 · NHLBI · UNIVERSITY OF WASHINGTON · PI DE BOER, IAN H, KESTENBAUM, BRYAN R · 2010 to 2019
$5.2M
Regional Dysfunction by MRI in Incident Heart FailureR01HL066075 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI LIMA, JOAO A C · 2001 to 2009
$4.0M
Multi-Scale Biology of Atherosclerosis in the Cellular Adhesion PathwayR01HL098077 · NHLBI · MAYO CLINIC ROCHESTER · PI BIELINSKI, SUZETTE JANINE · 2010 to 2014
$2.8M
Abdominal Body Composition, Inflammation and Cardiovascular DiseaaseR01HL088451 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALLISON, MATTHEW A · 2007 to 2011
$2.5M
Socioeconimic Patterning of Inflammation and HemostasisR01HL076831 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DIEZ-ROUX, ANA V. · 2004 to 2007
$2.5M
Endothelial Dysfunction and the RV in the Multi-Ethnic Study of AtherosclerosisR01HL086719 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2007 to 2010
$2.0M
Subclinical Renal Artery Atherosclerosis, Kidney Function and HypertensionR01DK080015 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALLISON, MATTHEW A · 2009 to 2011
$1.4M
Epidemiology of Vascular Inflammation &AtherosclerosisR01HL077449 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 2004 to 2007
$1.4M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NHLBI NIH HHS N01 HC095162NHLBI NIH HHS R01 HL066075NHLBI NIH HHS R01 HL074338NHLBI NIH HHS R01 HL074406NHLBI NIH HHS R01 HL076831NHLBI NIH HHS R01 HL077449NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL086719NHLBI NIH HHS R01 HL088451NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL096875NHLBI NIH HHS R01 HL098077NHLBI NIH HHS R21 HL091217NHLBI NIH HHS R21 HL109924NHLBI NIH HHS RC1 HL100543NIDA NIH HHS R21 DA024273NIDDK NIH HHS R01 DK080015NIH HHS HHSN263201500003I
6 · The paper itself

Abstract

When the MESA (Multi-Ethnic Study of Atherosclerosis) began, the Framingham risk score was the preferred tool for 10-year global coronary heart disease risk assessment; however, the Framingham risk score had limitations including derivation in a homogenous population lacking racial and ethnic diversity and exclusive reliance on traditional risk factors without consideration of most subclinical disease measures. MESA was designed to study the prognostic value of subclinical atherosclerosis and other risk markers in a multiethnic population. In a series of landmark publications, MESA demonstrated that measures of subclinical cardiovascular disease add significant prognostic value to the traditional Framingham risk variables. In head-to-head studies comparing these markers, MESA established that the coronary artery calcium score may be the single best predictor of coronary heart disease risk. Results from MESA have directly influenced recent prevention guidelines including the recommendations on risk assessment and cholesterol-lowering therapy. The MESA study has published its own risk score, which allows for the calculation of 10-year risk of coronary heart disease before and after knowledge of a coronary artery calcium score.

Indexed as

AgedAnkle Brachial IndexBiomarkersCarotid Intima-Media ThicknessCoronary Artery DiseaseCoronary DiseaseDisease ProgressionFemaleForecastingHumansMaleMiddle AgedPedigreePhysician-Patient RelationsPlaque, AtheroscleroticPractice Guidelines as TopicBiomarkers

Identifiers

PMID27741975
PMCPMC5117817
OpenAlexW2531506143

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.