ArticleVeterinary research2016
Immune protection of chickens conferred by a vaccine consisting of attenuated strains of Salmonella Enteritidis, Typhimurium and Infantis.
Article in Veterinary research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
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- Genetic engineering ofEcoSal Plus · 2024Review
- Pre-Harvest Non-TyphoidalAnimals : an open access journal from MDPI · 2024Review
- Chitosan-nanoparticle-based oral Salmonella enteritidis subunit vaccine elicits cross-protection against Salmonella typhimurium in broilers.Poultry science · 2024Article
- Holistic Strategies to ControlMicroorganisms · 2023Review
- Probiotic Lactobacilli Do Not Protect Chickens againstMicroorganisms · 2022Article
- Safety of theFrontiers in veterinary science · 2022Article
- Oral Deliverable Mucoadhesive Chitosan-International journal of nanomedicine · 2020Article
- Synbiotic supplementation to decrease Salmonella colonization in the intestine and carcass contamination in broiler birds.PloS one · 2019Article
- Genome sequencing and analysis ofPeerJ · 2019Article
- Demonstration of the efficacy of aHeliyon · 2018Article
- Surface engineered polyanhydride-based oralInternational journal of nanomedicine · 2018Article
- Characterization of Spleen Transcriptome and Immunity Against Avian Colibacillosis After Immunization With Recombinant AttenuatedFrontiers in veterinary science · 2018Article
- Immunogenic potential of a Salmonella Typhimurium live vaccine for pigs against monophasic Salmonella Typhimurium DT 193.BMC veterinary research · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The colonization of poultry with different Salmonella enterica serovars poses an issue throughout the world. In this study we therefore tested the efficacy of a vaccine consisting of attenuated strains of Salmonella enterica serovars Enteritidis, Typhimurium and Infantis against challenge with the same serovars and with S. Agona, Dublin and Hadar. We tested oral and aerosol administration of the vaccine, with or without co-administration of cecal microbiota from adult hens. The protective effect was determined by bacterial counts of the challenge strains up to week 18 of life and by characterizing the immune response using real-time PCR specific for 16 different genes. We have shown that a vaccine consisting of attenuated S. Enteritidis, S. Typhimurium and S. Infantis protected chickens against challenge with the wild type strains of the same serovars and partially protected chickens also against challenge with isolates belonging to serovars Dublin or Hadar. Aerosol vaccination was more effective at inducing systemic immunity whilst oral vaccination stimulated a local immune response in the gut. Co-administration of cecal microbiota increased the protectiveness in the intestinal tract but slightly decreased the systemic immune response. Adjusting the vaccine composition and changing the administration route therefore affects vaccine efficacy.
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Registered trials
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