ArticleOncotarget2016
Complex dissemination of the diversified mcr-1-harbouring plasmids in Escherichia coli of different sequence types.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Exploring current hypervirulentFrontiers in microbiology · 2025Review
- Navigating ESKAPE Pathogens: Considerations and Caveats for Animal Infection Models Development.ACS infectious diseases · 2024Review
- Worldwide Prevalence ofPathogens (Basel, Switzerland) · 2022Review
- Colistin ResistantVeterinary sciences · 2021Review
- Article
- Prevalence of Colistin-resistant Gram-negative Isolates Carrying the mcr-1 Gene among Patients Visiting a Tertiary Care Center.JNMA; journal of the Nepal Medical Association · 2020Article
- Occurrence and Molecular Characteristics ofAnimals : an open access journal from MDPI · 2020Article
- Isoalantolactone restores the sensitivity of gram-negative Enterobacteriaceae carrying MCR-1 to carbapenems.Journal of cellular and molecular medicine · 2020Article
- Definition of a Family of Nonmobile Colistin Resistance (NMCR-1) Determinants Suggests Aquatic Reservoirs for MCR-4.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Article
- Characterization of FiveFrontiers in microbiology · 2019Article
- Discovery of a mcr-1-bearing plasmid in commensal colistin-resistant Escherichia coli from healthy broilers in Faisalabad, Pakistan.Virulence · 2018Article
- Development of a pig infection model with colistin-resistant Escherichia coli.Veterinary microbiology · 2018Article
- Promoter Variation and Gene Expression ofAntimicrobial agents and chemotherapy · 2018Article
- Expression characteristics of the plasmid-borneOncotarget · 2017Article
- Genomic and Molecular Characterization of Clinical Isolates of Enterobacteriaceae HarboringAntimicrobial agents and chemotherapy · 2017Article
- Distinct mechanisms of acquisition of mcr-1 -bearing plasmid by Salmonella strains recovered from animals and food samples.Scientific reports · 2017Article
- Article
- Genomic Insights intoAntimicrobial agents and chemotherapy · 2017Article
- Deciphering MCR-2 Colistin Resistance.mBio · 2017Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of the mobilized colistin resistance gene, representing a novel mechanism for bacterial drug resistance, challenges the last resort against the severe infections by Gram-negative bacteria with multi-drug resistances. Very recently, we showed the diversity in the mcr-1-carrying plasmid reservoirs from the gut microbiota. Here, we reported that a similar but more complex scenario is present in the healthy swine populations, Southern China, 2016. Amongst the 1026 pieces of Escherichia coli isolates from 3 different pig farms, 302 E. coli isolates were determined to be positive for the mcr-1 gene (30%, 302/1026). Multi-locus sequence typing assigned no less than 11 kinds of sequence types including one novel Sequence Type to these mcr-1-positive strains. PCR analyses combined with the direct DNA sequencing revealed unexpected complexity of the mcr-1-harbouring plasmids whose backbones are at least grouped into 6 types four of which are new. Transcriptional analyses showed that the mcr-1 promoter of different origins exhibits similar activity. It seems likely that complex dissemination of the diversified mcr-1-bearing plasmids occurs amongst the various ST E. coli inhabiting the healthy swine populations, in Southern China.
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