Evidence map›Paper›PMID 27741513›Full record

ArticleOncotarget2016

CDKN2BAS polymorphisms are associated with coronary heart disease risk a Han Chinese population.

Qingbin Zhao, Shudan Liao, Huiyi Wei, Dandan Liu, Jingjie Li, Xiyang Zhang, Mengdan Yan, Tianbo Jin

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Effect of 9p21.3 (lncRNA and CDKN2A/2B) variant on lipid profile.Frontiers in cardiovascular medicine · 2022
    Pooled it
  2. Pooled it
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  9. Evaluation of the role ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018
    Article
  10. The impact of the AHSG genetic polymorphism on the risk of ischemic stroke: a case-control study.International journal of clinical and experimental pathology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Qingbin ZhaoDepartment of Geratology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Shudan LiaoDepartment of Cardiology, Xi'an Center Hospital, Xi'an, Shaanxi, China.
Huiyi WeiDepartment of Geratology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Dandan LiuDepartment of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jingjie LiKey Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi, China.
Xiyang ZhangXi'an Tiangen Precision Medical Institute, Xi'an, Shaanxi, China.
Mengdan YanKey Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi, China.
Tianbo JinKey Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi, China.
First Affiliated Hospital of Xi'an Jiaotong University · CNNorthwest University · CNFirst Hospital of Xi'an · CNMinistry of Education of the People's Republic of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The goal of our study was to determine whether CDKN2BAS polymorphisms are associated with coronary heart disease (CHD) risk in a Han Chinese population. Eight SNPs were genotyped in 676 men and 465 women. We used χ2 tests and genetic model analyses to evaluate associations between the SNPs and CHD risk. We found that rs10757274 was associated with an increased risk of CHD in both men (allele G: Odds ratio [OR] = 1.30, 95% confidence interval [CI]: 1.05-1.61, P = 0.018; codominant model: P = 0.042; recessive model: OR = 1.70, 95% CI: 1.10-2.62, P = 0.016; log-additive model: OR = 1.34, 95% CI: 1.05-1.71, P = 0.019) and women (dominant model: OR = 2.26, 95% CI: 1.28-3.99, P = 0.004). In addition, rs7865618 was associated with an 8.10-fold increased risk of CHD in women under a recessive model (OR = 8.10, 95% CI: 1.74-37.68, P = 0.006). Interestingly, the haplotype AA (rs10757274 and rs1333042) of CDKN2BAS was associated with decreased the risk of CHD in men (OR = 0.72, 95% CI: 0.55 - 0.95, P = 0.022).

Indexed as

Polymorphism, Single NucleotideAsian PeopleCase-Control StudiesChinaChi-Square DistributionCoronary DiseaseFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHaplotypesHeterozygoteHomozygoteHumansLogistic ModelsMaleCDKN2B antisense RNA, humanRNA, Long Noncodingcase-control,GerotargetCDKN2BAScoronary heart diseasesingle nucleotide polymorphisms

Identifiers

PMID27741513
PMCPMC5347672
OpenAlexW2531112210

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.