ArticleMedicine2016
Hepatocellular carcinoma after the Fontan procedure in a 16-year-old girl: A case report.
Article in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Surgical Treatment of Hepatocellular Carcinoma Arising from Fontan-associated Liver Disease: A Report of Three Cases.Internal medicine (Tokyo, Japan) · 2025Review
- Pediatric Hepatocellular Carcinoma: A Review of Predisposing Conditions, Molecular Mechanisms, and Clinical Considerations.International journal of molecular sciences · 2025Review
- Congenital cardiac liver cirrhosis with combined hepatocellular-cholangiocarcinoma-a case report.Journal of gastrointestinal oncology · 2022Article
- Care Pattern for Fontan-Associated Liver Disease by Academic Pediatric Hepatologists in Canada.JPGN reports · 2022Article
- Clinical complications of liver disease in adults after the Fontan operation.International journal of cardiology. Congenital heart disease · 2022Article
- Laparoscopic hysterectomy for endometrial cancer after the Fontan procedure: The first case report.International cancer conference journal · 2022Article
- Surveillance of Fontan-associated liver disease: current standards and a proposal from the European Society of Paediatric Radiology Abdominal Task Force.Pediatric radiology · 2021Article
- Pediatric Primary Hepatic Tumors: Diagnostic Considerations.Diagnostics (Basel, Switzerland) · 2021Review
- Fontan-associated liver disease and hepatocellular carcinoma in adults.Scientific reports · 2020Article
- A patient with post-Fontan operation underwent left hepatectomy and caudate lobectomy for hepatocellular carcinoma: a case report.Surgical case reports · 2020Article
- A case report of Fontan procedure-related hepatocellular carcinoma: pure laparoscopic approach by low and stable pneumoperitoneum.BMC surgery · 2020Article
- A case of Fontan-related hepatocellular carcinoma successfully treated with proton beam therapy.Clinical journal of gastroenterology · 2020Article
- Epidural anesthesia for emergency cesarean section in a woman with Fontan circulation: A case report.Medicine · 2020Article
- Hepatocellular nodules in vascular liver diseases.Virchows Archiv : an international journal of pathology · 2018Review
- Congestive hepatopathy: Differentiating congestion from fibrosis.Clinical liver disease · 2017Review
- Benign Hepatic Nodules Mimicking Hepatocellular Carcinoma in the Setting of Fontan-associated Liver Disease: A Case Report.Euroasian journal of hepato-gastroenterologyArticle
- An Emphasis on Screening to Detect Liver Cirrhosis and Hepatocellular Carcinoma in Patients Having Undergone the Fontan Procedure in Early Childhood.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe Fontan procedure (FP) has become the standard operation for patients with single ventricle physiology. However, a long period of elevated systemic venous pressure and low cardiac output after the procedure result in chronic inflammation and liver cirrhosis, which may eventually lead to the occurrence of hepatocellular carcinoma (HCC). CLINICAL
findingsWe described the case of a 16-year-old female who developed HCC after the FP. At 21 months, the patient received a lateral tunnel FP, and 14 years later, she began complaining of abdominal distension, telangiectasia, and fatigue. Imaging studies revealed a large hepatic mass involving most of the right lobe and multiple masses in the left lobe. Evidence suggested severe liver cirrhosis, and the presence of ascites, hepatosplenomegaly, paraesophageal gastric varices reflecting the severity of the disease. In addition, tumor thrombosis was found in the right hepatic vein, middle hepatic vein, and inferior vena cava, as well as multiple metastatic nodules in both lungs. The patient received an incisional biopsy and the diagnosis of HCC was pathologically confirmed. After treatment with 1 cycle of systemic chemotherapy, she received ongoing supportive care for disease-related complications, and died 2 months after chemotherapy due to hematemesis.
conclusionWith the advances in medicine, the incidence of Fontan physiology-related complications is likely to increase, and the incidence of HCC will also increase accordingly. As early diagnosis of HCC results in better patient outcomes, a surveillance guideline for HCC after the FP should be developed.
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