Evidence map›Paper›PMID 27741062›Full record

ArticleJournal of pediatric gastroenterology and nutrition2017

Oropharyngeal Dysphagia Is Strongly Correlated With Apparent Life-Threatening Events.

Daniel R Duncan, Janine Amirault, Paul D Mitchell, Kara Larson, Rachel L Rosen

3 registry-linked trialsOpen access · greenAbstract read
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03130543 naterminatednot on this map

A Randomized Trial of Thickened Feeds to Treat Gastroesophageal Reflux in Children Admitted to Boston Children's Hospital After Brief Resolved Unexplained Event

TypeinterventionalSponsorBoston Children's HospitalRan2017 to 2021Enrolled3ConditionsApparent Life Threatening Event, Gastroesophageal Reflux, AspirationArmsRice cereal, Enfamil AR
NCT04477460 recruitingnot on this mapstarted 2021, after this paper: background citation

Effect of Thickened Feeds on Clinical Outcomes in Children With Brief Resolved Unexplained Event

TypeobservationalSponsorBoston Children's HospitalRan2021 to 2026Enrolled250ConditionsBrief Resolved Unexplained Event, Apparent Life Threatening Event, Oropharyngeal DysphagiaArmsThickened feeds, Non-thickened feeds
NCT04504227 narecruitingnot on this mapstarted 2021, after this paper: background citation

Effect of Thickened Feeds on Swallow Physiology in Children With Dysphagia

TypeinterventionalSponsorBoston Children's HospitalRan2021 to 2026Enrolled200ConditionsDysphagia, Aspiration, Brief Resolved Unexplained Event (BRUE), Apparent Life Threatening Event (ALTE)ArmsThin liquid swallows, Slightly thickened liquid swallows, Mildly thickened liquid swallows, Moderately thickened liquid swallows
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Clinical outcomes before and after videofluoroscopic swallow study in children 24 months of age or younger.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2024
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Daniel R Duncan*Division of Gastroenterology, Hepatology and Nutrition, Aerodigestive Center †Clinical Research Program ‡Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, MA.
Janine Amirault
Paul D Mitchell
Kara Larson
Rachel L Rosen
Food and Nutrition Service · USBoston Children's Museum · USClinical Research Management · US

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAYNE I LENCER · 1986 to 2026
$32.4M
The impact of upper gastrointestinal dysmotility on aspiration-associated aerodigestive disorders in childrenR01DK097112 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI Rachel L Rosen · 2015 to 2026
$4.9M
NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK097112
6 · The paper itself

Abstract

objectivesThe aim of the present study was to investigate the prevalence of oropharyngeal dysfunction with resultant aspiration in patients admitted after apparent life-threatening events (ALTE) and to determine whether historical characteristics could predict this oropharyngeal dysphagia and aspiration risk.

methodsWe retrospectively reviewed the records of all patients admitted to Boston Children's Hospital between 2012 and 2015 with a diagnosis of ALTE to determine the frequency of evaluation for oropharyngeal dysphagia using video fluoroscopic swallow studies (VFSS) and clinical feeding evaluations, to determine the prevalence of swallowing dysfunction in subjects admitted after ALTE and to compare presenting historical characteristics to swallow study results.

resultsA total of 188 children were admitted with a diagnosis of ALTE of which 29% (n = 55) had an assessment of swallowing by VFSS. Of those who had a VFSS, 73% (n = 40) had evidence of aspiration or penetration on VFSS. Of all of the diagnostic tests ordered on patients with ALTEs, the VFSS had the highest rate of abnormalities of any test ordered. None of the historical characteristics of ALTE predicted which patients were at risk for aspiration. In patients who had both clinical feeding evaluations and VFSS, observed clinical feedings incorrectly identified 26% of patients as having no oropharyngeal dysphagia when in fact aspiration was present on VFSS.

conclusionsOropharyngeal dysphagia with aspiration is the most common diagnosis identified in infants presenting with ALTEs. The algorithm for ALTE should be revised to include an assessment of VFSS as clinical feeding evaluations are inadequate to assess for aspiration.

Indexed as

Brief, Resolved, Unexplained EventDeglutition DisordersFemaleHumansInfantInfant, NewbornMalePrevalenceRespiratory AspirationRetrospective StudiesRisk AssessmentRisk Factors

Identifiers

PMID27741062
PMCPMC5389921
OpenAlexW2531116777

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.