Evidence map›Paper›PMID 27740946›Full record

ArticlePhysics in medicine and biology2016

A multiplexed TOF and DOI capable PET detector using a binary position sensitive network.

M F Bieniosek, J W Cates, C S Levin

Abstract read
In one paragraph

Article in Physics in medicine and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M F BieniosekDepartment of Radiology, Stanford University, Stanford, CA 94305, USA.
J W CatesDepartment of Radiology, Stanford University, Stanford, CA 94305, USA.
C S LevinDepartment of Radiology, Stanford University, Stanford, CA 94305, USA.

Funding

Stanford Molecular Imaging Scholars - SMISR25CA118681 · NCI · STANFORD UNIVERSITY · PI LEVIN, CRAIG S · 2006 to 2015
$5.0M
Preclinical Translation of New Scintillation Light Detection Concepts for PETR01EB011552 · NIBIB · STANFORD UNIVERSITY · PI LEVIN, CRAIG S · 2011 to 2014
$1.9M
Photon interaction depth encoded time-of-flight PETR21EB014405 · NIBIB · STANFORD UNIVERSITY · PI LEVIN, CRAIG S · 2012 to 2013
$409k
Electro-optical Approach to Achieve Time-of-Flight PET/MRI for Cancer ImagingF31CA171573 · NCI · STANFORD UNIVERSITY · PI BIENIOSEK, MATTHEW · 2012 to 2015
$108k
NCI NIH HHS F31 CA171573NCI NIH HHS R25 CA118681NIBIB NIH HHS R01 EB011552NIBIB NIH HHS R21 EB014405
6 · The paper itself

Abstract

Time of flight (TOF) and depth of interaction (DOI) capabilities can significantly enhance the quality and uniformity of positron emission tomography (PET) images. Many proposed TOF/DOI PET detectors require complex readout systems using additional photosensors, active cooling, or waveform sampling. This work describes a high performance, low complexity, room temperature TOF/DOI PET module. The module uses multiplexed timing channels to significantly reduce the electronic readout complexity of the PET detector while maintaining excellent timing, energy, and position resolution. DOI was determined using a two layer light sharing scintillation crystal array with a novel binary position sensitive network. A 20 mm effective thickness LYSO crystal array with four 3 mm  ×  3 mm silicon photomultipliers (SiPM) read out by a single timing channel, one energy channel and two position channels achieved a full width half maximum (FWHM) coincidence time resolution of 180  ±  2 ps with 10 mm of DOI resolution and 11% energy resolution. With sixteen 3 mm  ×  3 mm SiPMs read out by a single timing channel, one energy channel and four position channels a coincidence time resolution 204  ±  1 ps was achieved with 10 mm of DOI resolution and 15% energy resolution. The methods presented here could significantly simplify the construction of high performance TOF/DOI PET detectors.

Indexed as

AlgorithmsElectronicsHumansImage Interpretation, Computer-AssistedPositron-Emission TomographyRadiometrySiliconSilicon

Identifiers

PMID27740946
PMCPMC5116435

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.