Evidence map›Paper›PMID 27740871›Full record

ArticleEndocrinology2016

Brown Adipose Tissue Function Is Enhanced in Long-Lived, Male Ames Dwarf Mice.

Justin Darcy, Samuel McFadden, Yimin Fang, Joshua A Huber, Chi Zhang, Liou Y Sun, Andrzej Bartke

Abstract read
In one paragraph

Article in Endocrinology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Thermogenic Adipose ADH5 Counteracts Age-related Metabolic Decline.bioRxiv : the preprint server for biology · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Transient early life growth hormone exposure permanently alters brain, muscle, liver, macrophage, and adipocyte status in long-lived Ames dwarf mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Mouse models of growth hormone deficiency.Reviews in endocrine & metabolic disorders · 2021
    Review
  19. Growth hormone and aging.Reviews in endocrine & metabolic disorders · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Justin DarcyDepartment of Internal Medicine (J.D., S.M., Y.F., J.A.H., C.Z., A.B.), Geriatric Research, and Department of Medical Microbiology, Immunology, and Cell Biology (J.D., A.B.), Southern Illinois University School of Medicine, Springfield, Illinois 62702; Institute of Cardiovascular Disease (C.Z.), Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, People's Republic of China; and Department of Biology (L.Y.S.), University of Alabama at Birmingham, Birmingham, Alabama 35294.
Samuel McFaddenDepartment of Internal Medicine (J.D., S.M., Y.F., J.A.H., C.Z., A.B.), Geriatric Research, and Department of Medical Microbiology, Immunology, and Cell Biology (J.D., A.B.), Southern Illinois University School of Medicine, Springfield, Illinois 62702; Institute of Cardiovascular Disease (C.Z.), Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, People's Republic of China; and Department of Biology (L.Y.S.), University of Alabama at Birmingham, Birmingham, Alabama 35294.
Yimin FangDepartment of Internal Medicine (J.D., S.M., Y.F., J.A.H., C.Z., A.B.), Geriatric Research, and Department of Medical Microbiology, Immunology, and Cell Biology (J.D., A.B.), Southern Illinois University School of Medicine, Springfield, Illinois 62702; Institute of Cardiovascular Disease (C.Z.), Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, People's Republic of China; and Department of Biology (L.Y.S.), University of Alabama at Birmingham, Birmingham, Alabama 35294.
Joshua A HuberDepartment of Internal Medicine (J.D., S.M., Y.F., J.A.H., C.Z., A.B.), Geriatric Research, and Department of Medical Microbiology, Immunology, and Cell Biology (J.D., A.B.), Southern Illinois University School of Medicine, Springfield, Illinois 62702; Institute of Cardiovascular Disease (C.Z.), Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, People's Republic of China; and Department of Biology (L.Y.S.), University of Alabama at Birmingham, Birmingham, Alabama 35294.
Chi ZhangDepartment of Internal Medicine (J.D., S.M., Y.F., J.A.H., C.Z., A.B.), Geriatric Research, and Department of Medical Microbiology, Immunology, and Cell Biology (J.D., A.B.), Southern Illinois University School of Medicine, Springfield, Illinois 62702; Institute of Cardiovascular Disease (C.Z.), Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, People's Republic of China; and Department of Biology (L.Y.S.), University of Alabama at Birmingham, Birmingham, Alabama 35294.
Liou Y SunDepartment of Internal Medicine (J.D., S.M., Y.F., J.A.H., C.Z., A.B.), Geriatric Research, and Department of Medical Microbiology, Immunology, and Cell Biology (J.D., A.B.), Southern Illinois University School of Medicine, Springfield, Illinois 62702; Institute of Cardiovascular Disease (C.Z.), Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, People's Republic of China; and Department of Biology (L.Y.S.), University of Alabama at Birmingham, Birmingham, Alabama 35294.
Andrzej BartkeDepartment of Internal Medicine (J.D., S.M., Y.F., J.A.H., C.Z., A.B.), Geriatric Research, and Department of Medical Microbiology, Immunology, and Cell Biology (J.D., A.B.), Southern Illinois University School of Medicine, Springfield, Illinois 62702; Institute of Cardiovascular Disease (C.Z.), Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, People's Republic of China; and Department of Biology (L.Y.S.), University of Alabama at Birmingham, Birmingham, Alabama 35294.

Funding

Longevity genes and calorie restriction: early post-natal effectsR01AG019899 · NIA · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · PI BARTKE, ANDRZEJ · 2001 to 2016
$6.1M
The effects of early life nutritional and hormonal signals on mammalian aging (Health Disparities Admin Supp)K01AG048264 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SUN, LIOU · 2014 to 2018
$784k
Aging at Thermoneutral TemperatureR21AG051869 · NIA · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · PI BARTKE, ANDRZEJ · 2016 to 2018
$490k
Methionine Restriction and Delay Aging: A Search for MechanismsR56AG050531 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SUN, LIOU · 2015 to 2015
$347k
NIA NIH HHS K01 AG048264NIA NIH HHS R01 AG019899NIA NIH HHS R21 AG051869NIA NIH HHS R56 AG050531
6 · The paper itself

Abstract

Ames dwarf mice (Prop1

Indexed as

Adipose Tissue, BrownAnimalsBody CompositionBody TemperatureCalorimetry, IndirectEnergy MetabolismHomeodomain ProteinsInsulin ResistanceLongevityMaleMiceMutationThermogenesisHomeodomain ProteinsProphet of Pit-1 protein

Identifiers

PMID27740871
PMCPMC5133358

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.