ReviewAnnals of the American Thoracic Society2016
The Clinical Significance of Collateral Ventilation.
Review in Annals of the American Thoracic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Use of dornase alfa in the paediatric intensive care unit: current literature and a national cross-sectional survey.European journal of hospital pharmacy : science and practice · 2022Pooled it
- Bronchoscopic Localization of a Post-Surgical Persistent Air Leak Facilitating Successful Treatment With a Hybrid Imaging-Guided Percutaneous Sealing of Fistula and Autologous Blood Patch Technique.Respirology case reports · 2026Article
- Nanoparticle-Based Pulmonary Immune Engineering.Annual review of chemical and biomolecular engineering · 2025Review
- Beneficial Effects of the Novel Digital Incentive Spirometer Device and Incentive Spirometer in Patients Undergoing Open-Heart Surgery: Randomized Controlled Trial.JMIR rehabilitation and assistive technologies · 2025Article
- A Novel Medical Device for Airway Clearance.Journal of clinical medicine · 2025Article
- CT-derived functional imaging biomarkers combined with FEV1 for predicting 10-year all-cause mortality in COPDGene cohort.npj biomedical innovations · 2025Article
- Use of mucolytics and inhaled antibiotics in the NICU.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Lung Volume Changes in Stable Preterm Infants Weaned From Nasal CPAP to High Flow: A Prospective Cohort Study.CHEST pulmonary · 2024Article
- Silence of the lungs: comparing measures of slow and noncommunicating lung units from pulmonary function tests with computed tomography.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Early association between respiratory mechanics and radiological changes in mechanically ventilated critically ill patients with COVID-19.Internal and emergency medicine · 2024Article
- Transarterial embolization of intralobar pulmonary sequestration in adult patients: A case series.Journal of clinical imaging science · 2024Article
- Risk and accuracy of outpatient-identified hypoxaemia for death among suspected child pneumonia cases in rural Bangladesh: a multifacility prospective cohort study.The Lancet. Respiratory medicine · 2023Article
- Structure and function of small airways in asthma patients revisited.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Rational use of mucoactive medications to treat pediatric airway disease.Paediatric respiratory reviews · 2020Review
- Physiological advantages of children against COVID-19.Acta paediatrica (Oslo, Norway : 1992) · 2020Article
- Nanoparticle Deposition in Rhythmically Moving Acinar Models with Interalveolar Septal Apertures.Nanomaterials (Basel, Switzerland) · 2019Article
- Guidelines for diagnostic flexible bronchoscopy in adults: Joint Indian Chest Society/National College of chest physicians (I)/Indian association for bronchology recommendations.Lung India : official organ of Indian Chest Society · 2019Article
- Compressive air trapping in asthma: effects of age, sex, and severity.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Asthma in Children and Adults-What Are the Differences and What Can They Tell us About Asthma?Frontiers in pediatrics · 2019Review
- Airflow and Particle Deposition in Acinar Models with Interalveolar Septal Walls and Different Alveolar Numbers.Computational and mathematical methods in medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Oxygen delivery and carbon dioxide removal being critical to cell survival, mammals have developed collateral vascular and ventilation systems to ensure tissue viability. Collateral ventilation, defined as ventilation of alveoli via pathways that bypass normal airways, is present in humans and many other species. The presence of collateral ventilation can be beneficial in certain disease states, whereas its relative absence can predispose to other diseases. These well defined anatomical pathways contribute little to ventilation in normal humans, but modulate ventilation perfusion imbalance in a variety of diseases, including obstructive diseases, such as asthma and emphysema. These pathways can be affected by pharmaceuticals and inhaled gas compositions. The middle lobe and lingula, constrained by their isolated, segmental anatomy, have reduced collateral ventilation, which predisposes them to disease. Recently, attempts to improve the quality of life of patients with emphysema, by performing nonsurgical lung volume reduction via use of endobronchial valves, have led to mixed results, because the role of collateral ventilation in the success or failure of the procedure was not initially appreciated. This review describes the anatomical pathways of collateral ventilation, their physiology and relationship to disease states, their modulatory effects on gas exchange, treatment considerations, and their effect on diagnostic procedures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.