Evidence map›Paper›PMID 27739661›Full record

ReviewACS chemical biology2016

Diazo Compounds: Versatile Tools for Chemical Biology.

Kalie A Mix, Matthew R Aronoff, Ronald T Raines

Open access · greenAbstract readReview
In one paragraph

Review in ACS chemical biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
11.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 229 citations in OpenAlex.

  1. Article
  2. Bis(silylene)-Mediated N═N Bond Scission of Diazo Compounds.Angewandte Chemie (International ed. in English) · 2026
    Article
  3. Article
  4. Article
  5. Properties of Bisdiazo Compounds and Their Derived Carbenes via Density Functional Theory.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026
    Article
  6. Hydrophilic α-Aryl-α-Diazoamides for Protein Esterification.Synlett : accounts and rapid communications in synthetic organic chemistry · 2025
    Article
  7. Review
  8. Article
  9. Structural Basis for the Catalytic Mechanism of ATP-Dependent Diazotase CmaA6.Angewandte Chemie (International ed. in English) · 2025
    Article
  10. Review
  11. Article
  12. Vitamin BRSC advances · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Kinetics of NACS omega · 2024
    Article
  17. LiOMolecules (Basel, Switzerland) · 2023
    Article
  18. Article
  19. Glutathione Mediates Control of Dual Differential Bio-orthogonal Labelling of Biomolecules.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kalie A MixDepartment of Biochemistry, University of Wisconsin-Madison , 433 Babcock Drive, Madison, Wisconsin 53706, United States.
Matthew R AronoffDepartment of Chemistry, University of Wisconsin-Madison , 1101 University Avenue, Madison, Wisconsin 53706, United States.
Ronald T RainesDepartment of Biochemistry, University of Wisconsin-Madison , 433 Babcock Drive, Madison, Wisconsin 53706, United States.
University of Wisconsin–Madison · US

Funding

GRADUATE TRAINING IN MOLECULAR BIOSCIENCEST32GM007215 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HULL, CHRISTINA M · 1985 to 2018
$22.5M
STRUCTURE--FUNCTION ANALYSIS OF RIBONUCLEASE AR01GM044783 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI RAINES, RONALD T · 1990 to 2021
$7.1M
NIGMS NIH HHS R01 GM044783NIGMS NIH HHS T32 GM007215
6 · The paper itself

Abstract

Diazo groups have broad and tunable reactivity. That and other attributes endow diazo compounds with the potential to be valuable reagents for chemical biologists. The presence of diazo groups in natural products underscores their metabolic stability and anticipates their utility in a biological context. The chemoselectivity of diazo groups, even in the presence of azido groups, presents many opportunities. Already, diazo compounds have served as chemical probes and elicited novel modifications of proteins and nucleic acids. Here, we review advances that have facilitated the chemical synthesis of diazo compounds, and we highlight applications of diazo compounds in the detection and modification of biomolecules.

Indexed as

AlkylationAmino AcidsAnimalsBiochemistryBiological ProductsCycloaddition ReactionDiazonium CompoundsHumansIndicators and ReagentsModels, MolecularNucleic AcidsProteinsAmino AcidsBiological ProductsDiazonium CompoundsIndicators and ReagentsNucleic AcidsProteins

Identifiers

PMID27739661
PMCPMC5161546
OpenAlexW2530985860

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.