ArticleJournal of neurochemistry2016
3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons.
Article in Journal of neurochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
157 citing papers in PubMed, 3 syntheses or guidelines pooled it, 230 citations in OpenAlex.
- Ketogenic interventions in mild cognitive impairment, Alzheimer's disease, and Parkinson's disease: A systematic review and critical appraisal.Frontiers in neurology · 2023Pooled it
- Pooled it
- Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer's disease. A systematic review and meta-analysis of human studies.Ageing research reviews · 2020Pooled it
- Ketone Ester Supplementation Improves Some Aspects of Cognitive Function during a Simulated Soccer Match after Induced Mental Fatigue.Nutrients · 2022Trial
- Trial
- Trial
- Neuronal ketone body utilization couples exercise and time-restricted feeding to cognitive enhancement.Molecular metabolism · 2026Article
- Systematic Evaluation of Structure-Property-Biocompatibility Relationships of Polyhydroxyalkanoate Copolymers for Advanced Veterinary Applications.Molecules (Basel, Switzerland) · 2026Article
- β-Hydroxybutyrate Exposure is Associated with Increased THCellular and molecular neurobiology · 2026Article
- Influence of Ketogenic Diet Lipid Composition on Anxiety-Like Behavior and Neurometabolic Profile in Healthy Rats.Molecular neurobiology · 2026Article
- Autophagy-Lysosomal Axis Stimulation by Beta-Hydroxybutyrate in Astrocytes.Molecular neurobiology · 2026Article
- Oral administration of MCT oil reduces anxiety-like behavior and is associated with differences in serum BDNF responses in a rat model of PTSD.Scientific reports · 2026Article
- Dietary restriction in aging and longevity.Nature aging · 2026Review
- The central benefit of physiologically induced ketogenic states.The Journal of physiology · 2026Review
- Neuronal ketone body utilization couples exercise and time-restricted feeding to cognitive enhancement.bioRxiv : the preprint server for biology · 2026Article
- Article
- Intermittent fasting and neuroprotection in Alzheimer's disease: metabolic mechanisms, cellular signaling, and brain-peripheral crosstalk.Frontiers in nutrition · 2026Review
- Ketones and brain health: from metabolic rescue to metabolic flexibility.Frontiers in nutrition · 2026Review
- Integrated analysis of proteomics and metabolomics reveals interactions of energy metabolism and reproduction in hypothalamus of chicken during sexual maturation.Journal of endocrinological investigation · 2025Article
- Targeting Neurodegeneration with SGLT2is: From Molecular Mechanisms to Clinical Implications.Molecular neurobiology · 2025Review
97 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
During fasting and vigorous exercise, a shift of brain cell energy substrate utilization from glucose to the ketone 3-hydroxybutyrate (3OHB) occurs. Studies have shown that 3OHB can protect neurons against excitotoxicity and oxidative stress, but the underlying mechanisms remain unclear. Neurons maintained in the presence of 3OHB exhibited increased oxygen consumption and ATP production, and an elevated NAD
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.