ArticlePrenatal diagnosis2016
Trial by Dutch laboratories for evaluation of non-invasive prenatal testing. Part II-women's perspectives.
Article in Prenatal diagnosis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Health literacy interventions for pregnant women with limited language proficiency in the country they live in: a systematic review.BMC public health · 2024Pooled it
- Health Literacy in Pregnant Women: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- Nuchal translucency of 3.0-3.4 mm an indication for NIPT or microarray? Cohort analysis and literature review.Acta obstetricia et gynecologica Scandinavica · 2020Pooled it
- Health Literacy among Pregnant Women in a Lifestyle Intervention Trial.International journal of environmental research and public health · 2022Trial
- Article
- Patient Preferences and Understanding of Genome-Wide Cell-Free DNA Screening for Foetal Chromosomal Imbalances: A Survey Study.Prenatal diagnosis · 2025Article
- Factors Influencing the Decision-Making Process for Undergoing Invasive Prenatal Testing.Cureus · 2024Review
- Health literacy and patient rights awareness in ethnic Hungarian mothers in Eastern Europe.Central European journal of public health · 2023Article
- Non-invasive prenatal testing (NIPT): is routinization problematic?BMC medical ethics · 2023Article
- Women's experiences with non-invasive prenatal testing in Switzerland: a qualitative analysis.BMC medical ethics · 2023Article
- Informed choice and routinization of the second-trimester anomaly scan: a national cohort study in the Netherlands.BMC pregnancy and childbirth · 2023Article
- Prenatal Diagnosis and Pregnancy Termination in Jewish and Muslim Women with a Deaf Child in Israel.Children (Basel, Switzerland) · 2023Article
- Preconception education program for non-invasive prenatal testing focused on interest in genetics among female university students in Japan: a quasi-experimental study comparing pre-intervention, post-intervention, and three-month follow-up results.Archives of public health = Archives belges de sante publique · 2023Article
- Preserving women's reproductive autonomy while promoting the rights of people with disabilities?: the case of Heidi Crowter and Maire Lea-Wilson in the light of NIPT debates in England, France and Germany.Journal of medical ethics · 2023Review
- Understanding the experiences and perspectives of prenatal screening among a diverse cohort.Prenatal diagnosis · 2023Article
- Patient experience with non-invasive prenatal testing (NIPT) as a primary screen for aneuploidy in the Netherlands.BMC pregnancy and childbirth · 2022Article
- Informed choice of pregnant women regarding noninvasive prenatal testing in Korea: a cross-sectional study.Korean journal of women health nursing · 2022Article
- Routinization of prenatal screening with the non-invasive prenatal test: pregnant women's perspectives.European journal of human genetics : EJHG · 2022Article
- Non-invasive prenatal testing (NIPT) and pregnant women's views on good motherhood: a qualitative study.European journal of human genetics : EJHG · 2022Article
- Maternal health literacy, utilisation of maternal healthcare services and pregnancy outcomes among newly delivered mothers: A cross-sectional study in Nigeria.Public health in practice (Oxford, England) · 2022Article
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate preferences and decision-making among high-risk pregnant women offered a choice between Non-Invasive Prenatal Testing (NIPT), invasive testing or no further testing.
methodsNationwide implementation study (TRIDENT) offering NIPT as contingent screening test for women at increased risk for fetal aneuploidy based on first-trimester combined testing (>1:200) or medical history. A questionnaire was completed after counseling assessing knowledge, attitudes and participation following the Multidimensional Measure of Informed Choice.
resultsA total of 1091/1253 (87%) women completed the questionnaire. Of these, 1053 (96.5%) underwent NIPT, 37 (3.4%) invasive testing and 1 (0.1%) declined testing. 91.7% preferred NIPT because of test safety. Overall, 77.9% made an informed choice, 89.8% had sufficient knowledge and 90.5% had positive attitudes towards NIPT. Women with intermediate (odds ratio (OR) = 3.51[1.70-7.22], p < 0.001) or high educational level (OR = 4.36[2.22-8.54], p < 0.001) and women with adequate health literacy (OR = 2.60[1.36-4.95], p = 0.004) were more likely to make an informed choice. Informed choice was associated with less decisional conflict and less anxiety (p < 0.001). Intention to terminate the pregnancy for Down syndrome was higher among women undergoing invasive testing (86.5%) compared to those undergoing NIPT (58.4%) (p < 0.001).
conclusionsThe majority of women had sufficient knowledge and made an informed choice. Continuous attention for counseling is required, especially for low-educated and less health-literate women. © 2016 The Authors. Prenatal Diagnosis published by John Wiley & Sons, Ltd.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.