ArticleScientific reports2016
Characterization of factors underlying the metabolic shifts in developing kernels of colored maize.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Decoding the Temporal Accumulation Pattern of Anthocyanins From Dynamic Expression of Purple aleurone1 Gene in Blue- and Red-kernel Maize Breeding Lines.Applied biochemistry and biotechnology · 2026Article
- Germination as a Strategy to Enhance the Bioactivity of Whole Grains: Phytochemical Remodeling and Health Implications.Comprehensive reviews in food science and food safety · 2026Review
- Breeding colored sweet corn for improved micronutrient content.Frontiers in plant science · 2026Article
- Integrated Metabolomics and Proteomics Analyses of the Grain-Filling Process and Differences in the Quality of Tibetan Hulless Barleys.Plants (Basel, Switzerland) · 2025Article
- Effect of Solvent and Grain Color on the Biological Activities of Maize Grain.Foods (Basel, Switzerland) · 2025Article
- Integrative transcriptome and metabolome analysis reveals the mechanisms of light-induced pigmentation in purple waxy maize.Frontiers in plant science · 2023Article
- High-quality genome assembly and multi-omics analysis of pigment synthesis pathway inFrontiers in microbiology · 2023Article
- A newly characterized allele of ZmR1 increases anthocyanin content in whole maize plant and the regulation mechanism of different ZmR1 alleles.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Maize Flavonoid Biosynthesis, Regulation, and Human Health Relevance: A Review.Molecules (Basel, Switzerland) · 2022Review
- Integrative metabolomic and transcriptomic analyses reveal the mechanisms of Tibetan hulless barley grain coloration.Frontiers in plant science · 2022Article
- Widely Targeted Metabolomics Analysis Reveals Key Quality-Related Metabolites in Kernels of Sweet Corn.International journal of genomics · 2021Article
- Promoting Human Nutrition and Health through Plant Metabolomics: Current Status and Challenges.Biology · 2020Review
- The Application of Metabolomics for the Study of Cereal Corn (Metabolites · 2020Review
- Intra-Kernel Reallocation of Proteins in Maize Depends on VP1-Mediated Scutellum Development and Nutrient Assimilation.The Plant cell · 2019Article
- Metabolic responses of rice source and sink organs during recovery from combined drought and heat stress in the field.GigaScience · 2019Article
- Isolation and Characterization of ThreeBiomolecules · 2019Article
- Integrated Metabolome and Transcriptome Analysis Uncovers the Role of Anthocyanin Metabolism inInternational journal of genomics · 2019Article
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elucidation of the metabolic pathways determining pigmentation and their underlying regulatory mechanisms in maize kernels is of high importance in attempts to improve the nutritional composition of our food. In this study, we compared dynamics in the transcriptome and metabolome between colored SW93 and white SW48 by integrating RNA-Seq and non-targeted metabolomics. Our data revealed that expression of enzyme coding genes and levels of primary metabolites decreased gradually from 11 to 21 DAP, corresponding well with the physiological change of developing maize kernels from differentiation through reserve accumulation to maturation, which was cultivar independent. A remarkable up-regulation of anthocyanin and phlobaphene pathway distinguished SW93 from SW48, in which anthocyanin regulating transcriptional factors (R1 and C1), enzyme encoding genes involved in both pathways and corresponding metabolic intermediates were up-regulated concurrently in SW93 but not in SW48. The shift from the shikimate pathway of primary metabolism to the flavonoid pathway of secondary metabolism, however, appears to be under posttranscriptional regulation. This study revealed the link between primary metabolism and kernel coloration, which facilitate further study to explore fundamental questions regarding the evolution of seed metabolic capabilities as well as their potential applications in maize improvement regarding both staple and functional foods.
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