Evidence map›Paper›PMID 27739464›Full record

ArticleScientific reports2016

NMR based serum metabolomics reveals a distinctive signature in patients with Lupus Nephritis.

Anupam Guleria, Avadhesh Pratap, Durgesh Dubey, Atul Rawat, Smriti Chaurasia, Edavalath Sukesh, Sanat Phatak, Sajal Ajmani, Umesh Kumar, Chunni Lal Khetrapal and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.

  1. Pooled it
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  14. Article
  15. Serum Metabolic Fingerprints Characterize Systemic Lupus Erythematosus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  16. Article
  17. Article
  18. Whole-Blood Metabolomics of a Rat Model of Repetitive Concussion.Journal of molecular neuroscience : MN · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Anupam GuleriaCentre of Biomedical Research, SGPGIMS Campus, Lucknow-226014, India.
Avadhesh PratapDepartment of Immunology, SGPGIMS Campus, Lucknow-226014, India.
Durgesh DubeyCentre of Biomedical Research, SGPGIMS Campus, Lucknow-226014, India.
Atul RawatCentre of Biomedical Research, SGPGIMS Campus, Lucknow-226014, India.
Smriti ChaurasiaDepartment of Immunology, SGPGIMS Campus, Lucknow-226014, India.
Edavalath SukeshDepartment of Immunology, SGPGIMS Campus, Lucknow-226014, India.
Sanat PhatakDepartment of Immunology, SGPGIMS Campus, Lucknow-226014, India.
Sajal AjmaniDepartment of Immunology, SGPGIMS Campus, Lucknow-226014, India.
Umesh KumarCentre of Biomedical Research, SGPGIMS Campus, Lucknow-226014, India.
Chunni Lal KhetrapalCentre of Biomedical Research, SGPGIMS Campus, Lucknow-226014, India.
Paul BaconRheumatology Research Group, Division of Immunity and Infection, Birmingham University, UK.
Ramnath MisraDepartment of Immunology, SGPGIMS Campus, Lucknow-226014, India.
Dinesh KumarCentre of Biomedical Research, SGPGIMS Campus, Lucknow-226014, India.
Sanjay Gandhi Post Graduate Institute of Medical Sciences · INCentre of Biomedical Research · INUniversity of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Management of patient with Lupus Nephritis (LN) continues to remain a challenge for the treating physicians because of considerable morbidity and even mortality. The search of biomarkers in serum and urine is a focus of researchers to unravel new targets for therapy. In the present study, the utility of NMR-based serum metabolomics has been evaluated for the first time in discriminating LN patients from non-nephritis lupus patients (SLE) and further to get new insights into the underlying disease processes for better clinical management. Metabolic profiling of sera obtained from 22 SLE patients, 40 LN patients and 30 healthy controls (HC) were performed using high resolution 1D

Indexed as

MetabolomicsAdultBiomarkersFemaleHumansLipid MetabolismLipidsLupus NephritisMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedBiomarkersLipids

Identifiers

PMID27739464
PMCPMC5064370
OpenAlexW2531766156

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.