ReviewDevelopment and psychopathology2016
Understanding comorbidity among internalizing problems: Integrating latent structural models of psychopathology and risk mechanisms.
Review in Development and psychopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Developmentally Informed Systematic Review and Meta-Analysis of the Strength of General Psychopathology in Childhood and Adolescence.Clinical child and family psychology review · 2024Pooled it
- The Transdiagnostic Origins of Anxiety and Depression During the Pediatric Period: Linking NIMH Research Domain Criteria (RDoC) Constructs to Ecological Systems.Development and psychopathology · 2021Pooled it
- Dose‒Response Effects of Patient Engagement on Anxiety and Depression in a Cognitive-Behavioral Intervention: Secondary Analysis of a Pilot Randomized Controlled Trial and a Clinical Controlled Trial.AIDS and behavior · 2024Trial
- An experimental test of the fetal programming hypothesis: Can we reduce child ontogenetic vulnerability to psychopathology by decreasing maternal depression?Development and psychopathology · 2018Trial
- Language of Perseverative Thoughts Predicts Emotion Regulation Strategy Choice.Affective science · 2026Article
- Depression symptoms relate to altered brain connectivity and behavioral responses during self-referential judgments.Cognitive, affective & behavioral neuroscience · 2026Article
- The use of neuropsychological tasks to evaluate self-regulation in depression and anxiety during adolescence: a scoping review.Acta neuropsychiatrica · 2026Article
- Eveningness in Middle-Aged and Older Adults: Associations With Sleep, Internalising Symptoms, and Alertness.Journal of sleep research · 2026Article
- A Network Analysis of Panic Disorder, Agoraphobia, and Generalized Anxiety Disorder in 463 Patients From a Psychiatric Hospital.Brain and behavior · 2026Article
- Self-Concept Clarity and AI Anxiety in Graduate Students: Mediating Roles of Intentional Self-Regulation and Perceived Stress and Moderating Role of Intolerance of Uncertainty.Behavioral sciences (Basel, Switzerland) · 2026Article
- Bidirectional Associations Between Cyberbullying Victimization, Non-Suicidal Self-Injury, and Depressive Symptoms in Adolescents.Journal of adolescence · 2026Article
- Neurocognitive Biotypes of Risk and Resilience for Mood Disorders in Adolescents: Insights From Behavioral and Graph-Theoretic Network Markers.Biological psychiatry global open science · 2025Article
- Intrinsic Functional Connectivity Associated with γ‑Aminobutyric Acid and Glutamate/Glutamine in the Lateral Prefrontal Cortex and Internalizing Psychopathology in Adolescents.Neuroscience bulletin · 2025Article
- Individual differences in intolerance of uncertainty is primarily linked to the structure of inferior frontal regions.Cognitive, affective & behavioral neuroscience · 2025Article
- The Depression Anxiety Stress Scales for Youth (DASS-Y): evidence of validity and cross-national and gender measurement invariance.European child & adolescent psychiatry · 2025Article
- Higher prenatal dietary glycemic index in the third trimester of pregnancy is associated with infant negative affect at 6 months.Scientific reports · 2025Article
- The effects of shared, depression-specific, and anxiety-specific internalizing symptoms on negative and neutral episodic memories following post-learning sleep.Cognitive, affective & behavioral neuroscience · 2025Article
- Maternal depression during the perinatal period: the role of Sensory Processing Sensitivity and social support and its impact on infants' negative affect.Frontiers in psychology · 2025Article
- Investigating Trivariate Associations Between Risky Sexual Behavior, Internalizing Problems, and Externalizing Problems: A Twin Study.Behavior genetics · 2024Article
- Sex differences in physiological correlates of affectively driven decision-making behavior in adult ADHD.BMC psychiatry · 2024Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
It is well known that comorbidity is the rule, not the exception, for categorically defined psychiatric disorders, and this is also the case for internalizing disorders of depression and anxiety. This theoretical review paper addresses the ubiquity of comorbidity among internalizing disorders. Our central thesis is that progress in understanding this co-occurrence can be made by employing latent dimensional structural models that organize psychopathology as well as vulnerabilities and risk mechanisms and by connecting the multiple levels of risk and psychopathology outcomes together. Different vulnerabilities and risk mechanisms are hypothesized to predict different levels of the structural model of psychopathology. We review the present state of knowledge based on concurrent and developmental sequential comorbidity patterns among common discrete psychiatric disorders in youth, and then we advocate for the use of more recent bifactor dimensional models of psychopathology (e.g., p factor; Caspi et al., 2014) that can help to explain the co-occurrence among internalizing symptoms. In support of this relatively novel conceptual perspective, we review six exemplar vulnerabilities and risk mechanisms, including executive function, information processing biases, cognitive vulnerabilities, positive and negative affectivity aspects of temperament, and autonomic dysregulation, along with the developmental occurrence of stressors in different domains, to show how these vulnerabilities can predict the general latent psychopathology factor, a unique latent internalizing dimension, as well as specific symptom syndrome manifestations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.