ArticleDevelopment and psychopathology2016
Transdiagnostic factors and pathways to multifinality: The error-related negativity predicts whether preschool irritability is associated with internalizing versus externalizing symptoms at age 9.
Article in Development and psychopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Understanding irritability through the lens of self-regulatory control processes in children and adolescents: a systematic review.European child & adolescent psychiatry · 2025Pooled it
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Systematic Review and Meta-Analysis: Early Irritability as a Transdiagnostic Neurodevelopmental Vulnerability to Later Mental Health Problems.Journal of the American Academy of Child and Adolescent Psychiatry · 2024Pooled it
- Age-related differences in the error-related negativity and error positivity in children and adolescents are moderated by sample and methodological characteristics: A meta-analysis.Psychophysiology · 2022Pooled it
- Dysregulated Irritability as a Window on Young Children's Psychiatric Risk: Transdiagnostic Effects via the Family Check-Up.Development and psychopathology · 2019Trial
- Locus-Coeruleus Norepinephrine Functioning as a Predictor of Childhood Mental Health (LOCUS-MENTAL): Protocol for a Longitudinal Study.JMIR research protocols · 2026Article
- Error-related brain activity shapes the association between trait neuroticism and internalizing symptomatology in two tasks.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024Article
- An Expanded Conceptual Framework for Understanding Irritability in Childhood: The Role of Cognitive Control Processes.Clinical child and family psychology review · 2024Review
- Irritability as a Transdiagnostic Risk Factor for Functional Impairment in Autistic and Non-autistic Toddlers and Preschoolers.Research on child and adolescent psychopathology · 2024Article
- Advancing earlier transdiagnostic identification of mental health risk: A pragmatic approach at the transition to toddlerhood.International journal of methods in psychiatric research · 2023Article
- Cross-sectional and Longitudinal Associations of Anxiety and Irritability With Adolescents' Neural Responses to Cognitive Conflict.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Inhibitory Control in Early Childhood Aggression Subtypes: Mediation by Irritability.Child psychiatry and human development · 2023Article
- EEG Dynamics of Error Processing and Associated Behavioral Adjustments in Preschool Children.Brain sciences · 2023Article
- Eye-movement indices of arousal predict ADHD and comorbid externalizing symptoms over a 2-year period.Scientific reports · 2023Article
- Joint Consideration of Inhibitory Control and Irritability in Young Children: Contributions to Emergent Psychopathology.Research on child and adolescent psychopathology · 2022Article
- Developmental patterning of irritability enhances prediction of psychopathology in preadolescence: Improving RDoC with developmental science.Journal of psychopathology and clinical science · 2022Article
- Preschool Irritability Predicts Adolescent Psychopathology and Functional Impairment: A 12-Year Prospective Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2022Article
- Calibrating temper loss severity in the transition to toddlerhood: Implications for developmental science.Applied developmental science · 2022Article
- Translating RDoC to Real-World Impact in Developmental Psychopathology: A Neurodevelopmental Framework for Application of Mental Health Risk Calculators.Development and psychopathology · 2021Article
- A Transdiagnostic Perspective on Youth Irritability.Current directions in psychological science · 2021Article
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7 authors.
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Abstract
There is increasing interest among developmental psychopathologists in broad transdiagnostic factors that give rise to a wide array of clinical presentations (multifinality), but little is known about how these processes lead to particular psychopathological manifestations over the course of development. We examined whether individual differences in the error-related negativity (ΔERN), a neural indicator of error monitoring, predicts whether early persistent irritability, a prototypical transdiagnostic construct, is associated with later internalizing versus externalizing outcomes. When children were 3 years old, mothers were interviewed about children's persistent irritability and completed questionnaires about their children's psychopathology. Three years later, EEG was recorded while children performed a go/no-go task to measure the ΔERN. When children were approximately 9 years old, mothers again completed questionnaires about their children's psychopathology. The results indicated that among children who were persistently irritable at age 3, an enhanced or more negative ΔERN at age 6 predicted the development of internalizing symptoms at age 9, whereas a blunted or smaller ΔERN at age 6 predicted the development of externalizing symptoms. Our results suggest that variation in error monitoring predicts, and may even shape, the expression of persistent irritability and differentiates developmental trajectories from preschool persistent irritability to internalizing versus externalizing outcomes in middle to late childhood.
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