Evidence map›Paper›PMID 27739327›Full record

ArticleFuture medicinal chemistry2016

Activity of caffeic acid phenethyl ester in Caenorhabditis elegans.

Jeffrey J Coleman, Tomomi Komura, Julia Munro, Michael P Wu, Rakhee R Busanelli, Angela N Koehler, Méryl Thomas, Florence F Wagner, Edward B Holson, Eleftherios Mylonakis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future medicinal chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. The Anti-Biofilm Efficacy of Caffeic Acid Phenethyl Ester (CAPE)Frontiers in cellular and infection microbiology · 2021
    Article
  8. Review
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Jeffrey J ColemanDivision of Infectious Diseases, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI 02903, USA.
Tomomi KomuraDivision of Infectious Diseases, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI 02903, USA.
Julia MunroMIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA.
Michael P WuMIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA.
Rakhee R BusanelliChemical Biology Program, Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA.
Angela N KoehlerChemical Biology Program, Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA.
Méryl ThomasChemical Biology Program, Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA.
Florence F WagnerChemical Biology Program, Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA.
Edward B HolsonChemical Biology Program, Broad Institute of MIT & Harvard, Cambridge, MA 02142, USA.
Eleftherios MylonakisDivision of Infectious Diseases, Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI 02903, USA.
Broad Institute · USBrown University · USHarvard–MIT Division of Health Sciences and Technology · USHarvard University · USKoch Institute for Integrative Cancer Research At MIT

Funding

Technical Mother Machine CoreP01AI083214 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI Michael S Gilmore · 2009 to 2026
$39.4M
Targeting Causal Cancer Genes with Small MoleculesRC2CA148399 · NCI · BROAD INSTITUTE, INC. · PI SCHREIBER, STUART L · 2009 to 2012
$5.2M
NCI NIH HHS RC2 CA148399NIAID NIH HHS P01 AI083214
6 · The paper itself

Abstract

aimCaffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE), the major constituent of propolis, is able to increase the survival of the nematode Caenorhabditis elegans after infection with the fungal pathogen Candida albicans.

resultsCAPE increases the expression of several antimicrobial proteins involved in the immune response to C. albicans. Structural derivatives of CAPE were synthesized to identify structure-activity relationships and decrease metabolic liability, ultimately leading to a compound that has similar efficacy, but increased in vivo stability. The CED-10(Rac-1)/PAK1 pathway was essential for immunomodulation by CAPE and was a critical component involved in the immune response to fungal pathogens.

conclusionCaenorhabditis elegans is an efficient heterologous host to evaluate immunomodulatory compounds and identify components of the pathway(s) involved in the mode of action of compounds.

Indexed as

caffeic acid phenethyl esterCandidainnate immune responsep21 kinasepropolis

Identifiers

PMID27739327
PMCPMC6161127
OpenAlexW2529920575

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.