Evidence map›Paper›PMID 27739249›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2017

Design of Hydrated Porphyrin-Phospholipid Bilayers with Enhanced Magnetic Resonance Contrast.

Shuai Shao, Trang Nhu Do, Aida Razi, Upendra Chitgupi, Jumin Geng, Richard J Alsop, Boris G Dzikovski, Maikel C Rheinstädter, Joaquin Ortega, Mikko Karttunen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Labeling of Erythrocytes by Porphyrin-Phospholipid.Advanced nanobiomed research · 2021
    Article
  5. Article
  6. Article
  7. Review
  8. IntrabilayerACS nano · 2017
    Article
  9. Article
  10. Review
  11. Microwave-assisted synthesis of [Nuclear medicine and biology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shuai ShaoDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Trang Nhu DoDepartment of Chemistry and Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L3G1, Canada.
Aida RaziDepartment of Biochemistry and Biomedical Sciences and M. G. DeGroote Institute for Infectious Diseases Research, McMaster University, Hamilton, Ontario, L8S4L8, Canada.
Upendra ChitgupiDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Jumin GengDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.
Richard J AlsopDepartment of Physics and Astronomy, McMaster University, Hamilton, Ontario, L8S4M1, Canada.
Boris G DzikovskiDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Maikel C RheinstädterDepartment of Physics and Astronomy, McMaster University, Hamilton, Ontario, L8S4M1, Canada.
Joaquin OrtegaDepartment of Biochemistry and Biomedical Sciences and M. G. DeGroote Institute for Infectious Diseases Research, McMaster University, Hamilton, Ontario, L8S4L8, Canada.
Mikko KarttunenDepartment of Chemistry and Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L3G1, Canada.
Joseph A SpernyakDepartment of Cell Stress Biology, Roswell Park Cancer Institute Buffalo, NY, 14263, USA.
Jonathan F LovellDepartment of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA.

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
TR&D 4 for ACERT, 2017-2021 funding periodP41GM103521 · NIGMS · CORNELL UNIVERSITY · PI FREED, JACK H · 2012 to 2021
$11.7M
Light-Triggered Drug Release in Primed Pancreatic TumorsR01EB017270 · NIBIB · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LOVELL, JONATHAN F · 2013 to 2021
$3.5M
Targeting Tumors with Resealable Nanovesicles Permeabilized by NIR LightDP5OD017898 · OD · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI LOVELL, JONATHAN F · 2013 to 2017
$1.9M
NCATS NIH HHS UL1 TR001412NCI NIH HHS P30 CA016056NIBIB NIH HHS R01 EB017270NIGMS NIH HHS P41 GM103521NIH HHS DP5 OD017898
6 · The paper itself

Abstract

Computer simulations are used to design more hydrated bilayers, formed from amine-modified porphyrin-phospholipids (PoPs). Experiments confirm that the new constructs give rise to bilayers with greater water content. When chelated with manganese, amine-modified PoPs provide improved contrast for magnetic resonance and are safely used for imaging in vivo.

Indexed as

Magnetic Resonance SpectroscopyContrast MediaLipid BilayersLiposomesMolecular Dynamics SimulationPhospholipidsPorphyrinsWaterContrast MediaLipid BilayersLiposomesPhospholipidsPorphyrinsWaterbilayerscontrast agentsMD simulationsporphyrin-phospholipidwater permeation

Identifiers

PMID27739249
PMCPMC5209247

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.