Evidence map›Paper›PMID 27739164›Full record

ArticleAddiction biology2017

Evidence for GABA-A receptor dysregulation in gambling disorder: correlation with impulsivity.

Inge Mick, Anna C Ramos, Jim Myers, Paul R Stokes, Samantha Chandrasekera, David Erritzoe, Maria A Mendez, Roger N Gunn, Eugenii A Rabiner, Graham E Searle and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Addiction biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. GABAFrontiers in neuroscience · 2020
    Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Observational
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Inge MickCentre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK.
Anna C RamosCentre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK.
Jim MyersCentre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK.
Paul R StokesCentre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK.
Samantha ChandrasekeraCentre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK.
David ErritzoeCentre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK.
Maria A MendezForensic and Neurodevelopmental Sciences, Institute of Psychiatry, King's College, UK.
Roger N GunnCentre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK.
Eugenii A RabinerImanova Ltd., Centre for Imaging Sciences, UK.
Graham E SearleImanova Ltd., Centre for Imaging Sciences, UK.
José C F GaldurózDepartment of Psychobiology, Universidade Federal de São Paulo, Brazil.
Adam D WaldmanDepartment of Imaging, Division of Experimental Medicine, Department of Medicine, Imperial College, UK.
Henrietta Bowden-JonesNational Problem Gambling Clinic, CNWL NHS Foundation Trust, Imperial College London, UK.
Luke ClarkCentre for Gambling Research at UBC, Department of Psychology, University of British Columbia, Canada.
David J NuttCentre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK.
Anne R Lingford-HughesCentre for Neuropsychopharmacology, Division of Brain Sciences, Faculty of Medicine, Imperial College London, UK.
Imperial College London · GBKing's College London · GBUniversidade Federal de São Paulo · BRGreo · CALivaNova (United Kingdom) · GB

Funding

Medical Research Council G1002226
6 · The paper itself

Abstract

As a behavioural addiction, gambling disorder (GD) provides an opportunity to characterize addictive processes without the potentially confounding effects of chronic excessive drug and alcohol exposure. Impulsivity is an established precursor to such addictive behaviours, and GD is associated with greater impulsivity. There is also evidence of GABAergic dysregulation in substance addiction and in impulsivity. This study therefore investigated GABA

Indexed as

AdultAzidesBehavior, AddictiveBenzodiazepinesBrainCarbon RadioisotopesGamblingHumansImpulsive BehaviorMalePositron-Emission TomographyReceptors, GABA-AAzidesBenzodiazepinesCarbon RadioisotopesReceptors, GABA-ARo 15-4513[11C]Ro15-4513 PETGABA systemgambling disorder

Identifiers

PMID27739164
PMCPMC5697606
OpenAlexW2525063762

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.