ArticleChild development2017
The Signature of Maternal Social Rank in Placenta Deoxyribonucleic Acid Methylation Profiles in Rhesus Monkeys.
Article in Child development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Prenatal social support in low-risk pregnancy shapes placental epigenome.BMC medicine · 2023Trial
- Social bonds decrease epigenetic age in male bottlenose dolphins.Communications biology · 2025Article
- Epigenetic signatures of social status in wild female spotted hyenas (Crocuta crocuta).Communications biology · 2024Article
- First Steps towards the Development of Epigenetic Biomarkers in Female Cheetahs (Life (Basel, Switzerland) · 2022Article
- Epigenomics and gene regulation in mammalian social systems.Current zoology · 2020Article
- The epigenetics of perinatal stress .Dialogues in clinical neuroscience · 2019Review
- Midlife reversibility of early-established biobehavioral risk factors: A research agenda.Developmental psychology · 2019Article
- Socioeconomic status and DNA methylation from birth through mid-childhood: a prospective study in Project Viva.Epigenomics · 2019Article
- Interindividual differences in neonatal sociality and emotionality predict juvenile social status in rhesus monkeys.Developmental science · 2019Article
- Social status alters chromatin accessibility and the gene regulatory response to glucocorticoid stimulation in rhesus macaques.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Sex and rank affect how infant rhesus macaques look at faces.Developmental psychobiology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
The effects of social status on human health can be modeled in captive cohorts of nonhuman primates. This study shows that maternal social rank is associated with broad changes in DNA methylation in placentae of rhesus monkeys (N = 10). Differentially methylated genes between social ranks are enriched in signaling pathways playing major roles in placenta physiology. Moreover, the authors found significant overlaps with genes whose expression was previously associated with social rank in adult rhesus monkeys (Tung et al., 2012) and whose methylation was associated with perinatal stress in newborn humans and rhesus monkeys (Nieratschker et al., 2014). These results are consistent with the hypothesis that system-wide epigenetic changes in multiple tissues are involved in long-term adaptations to the social environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.