Evidence map›Paper›PMID 27739024›Full record

ArticleAdvances in experimental medicine and biology2018

Expression of Inflammatory Mediators in Induced Sputum: Comparative Study in Asthma and COPD.

Magdalena Paplińska-Goryca, Patrycja Nejman-Gryz, Katarzyna Górska, Katarzyna Białek-Gosk, Joanna Hermanowicz-Salamon, Rafał Krenke

Erratum issuedOpen access · hybridAbstract readComparative Study
PubMed Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
11.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Neuroimmune Pathophysiology in Asthma.Frontiers in cell and developmental biology · 2021
    Review
  5. Review
  6. Article
  7. Mixed Th2 and non-Th2 inflammatory pattern in the asthma-COPD overlap: a network approach.International journal of chronic obstructive pulmonary disease · 2018
    Observational
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Magdalena Paplińska-GorycaDepartment of Internal Medicine, Pneumology and Allergology, Warsaw Medical University, 1A Banacha Street, 02-097, Warsaw, Poland. mpaplinska@wum.edu.pl.
Patrycja Nejman-GryzDepartment of Internal Medicine, Pneumology and Allergology, Warsaw Medical University, 1A Banacha Street, 02-097, Warsaw, Poland.
Katarzyna GórskaDepartment of Internal Medicine, Pneumology and Allergology, Warsaw Medical University, 1A Banacha Street, 02-097, Warsaw, Poland.
Katarzyna Białek-GoskDepartment of Internal Medicine, Pneumology and Allergology, Warsaw Medical University, 1A Banacha Street, 02-097, Warsaw, Poland.
Joanna Hermanowicz-SalamonDepartment of Internal Medicine, Pneumology and Allergology, Warsaw Medical University, 1A Banacha Street, 02-097, Warsaw, Poland.
Rafał KrenkeDepartment of Internal Medicine, Pneumology and Allergology, Warsaw Medical University, 1A Banacha Street, 02-097, Warsaw, Poland.
Medical University of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asthma and COPD are the most common obstructive lung diseases characterized by inflammation in the lower airways which contribute to airflow limitation. Different inflammatory mediators are thought to play a key role in these diseases. This study was conducted in 13 patients with asthma, 12 patients with COPD, and 13 control subjects. The expression of mRNA of IL-6, IL-13, CXCL8, TSLP, IL-33, IL-25, IL-17, ECP, mast cell tryptase, CCL24, and CCL26 was assessed in induced sputum cells by real time PCR. We found that CXCL8 was strongly related to the neutrophil percentage but differed significantly in COPD and asthma patients. The expression of IL-17 was lower in patients with atopic asthma compared to non-atopic asthma. The percentage of macrophages correlated negatively with the expression of mast cell tryptase and ECP in COPD, and with CXCL8 in asthma. The expression of ECP correlated negatively with the severity of COPD symptoms measured by CAT. We conclude that asthma and COPD demonstrate a significant overlap in the airway cytokine profile. Thus, differentiation between the two diseases is difficult as based on a single cytokine, which suggests the coexistence of phenotypes sharing a common cytokine network in these obstructive lung diseases.

Indexed as

AdultAgedAged, 80 and overAsthmaCytokinesEosinophilsFemaleHumansInflammationInflammation MediatorsMaleMiddle AgedPulmonary Disease, Chronic ObstructiveSputumYoung AdultCytokinesInflammation MediatorsAirwayAsthmaCOPDCXCL8EosinophilsIL-17IL-6InflammationMediatorsNeutrophilsRespiration

Identifiers

PMID27739024
OpenAlexW2531516703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.