ReviewCurrent hypertension reports2016
Isolated Systolic Hypertension in Young and Middle-Aged Adults.
Review in Current hypertension reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Association between remnant cholesterol and isolated diastolic hypertension in young adults: a cross-sectional study in China.BMC cardiovascular disorders · 2026Article
- Integrative, multimodal nursing intervention for uncontrolled hypertension: randomized controlled trial effects on blood pressure, perceived stress, and medication adherence.Clinical hypertension · 2026Article
- Amlodipine-Based Therapy and Its Effect on Time in Target Range and Long-Term Blood Pressure Variability Across Age Groups in Chinese Patients With Primary Hypertension: A Retrospective Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Prevalence of hypertension and high-normal blood pressure among young adults in Zimbabwe: findings from a large, cross-sectional population-based survey.The Lancet. Child & adolescent health · 2024Article
- Association of waist circumference and BMI with premature death in young and middle-aged population.Frontiers in public health · 2024Article
- Pulse Wave Analysis in Obese Children with and without Metabolic SyndromeJournal of clinical research in pediatric endocrinology · 2023Article
- The Impact of Different Antihypertensive Drugs on Cardiovascular Risk in Isolated Systolic Hypertension with Type 2 Diabetes Patients.Journal of clinical medicine · 2022Article
- Vitamin D and family history of hypertension in relation to hypertension status among college students.Journal of human hypertension · 2022Article
- Approach to Hypertension in Adolescents and Young Adults.Current cardiology reports · 2022Review
- Isolated systolic hypertension and insulin resistance assessment tools in young and middle-aged Chinese men with normal fasting glucose: a cross-sectional study.Scientific reports · 2022Article
- Psychometric evaluation of the healthy aging activity engagement scale.Frontiers in public health · 2022Article
- Isolated systolic hypertension in young males: a scoping review.Clinical hypertension · 2021Article
- Cardiovascular risk assessment in children and adolescents with congenital solitary kidneys.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Should we need more sensitive early diagnostic markers in children with congenital solitary functioning kidneys?Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Impact of Methodological and Calibration Approach on the Association of Central and Peripheral Systolic Blood Pressure with Cardiac Structure and Function in Children, Adolescents and Adults.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2019Article
- Central systolic blood pressure and central pulse pressure predict left ventricular hypertrophy in hypertensive children.Pediatric nephrology (Berlin, Germany) · 2019Article
- Cardiac magnetic resonance assessment of central and peripheral vascular function in patients undergoing renal sympathetic denervation as predictor for blood pressure response.Clinical research in cardiology : official journal of the German Cardiac Society · 2018Article
- Evaluation of lipid profile and its relationship with blood pressure in patients with Cushing's disease.Endocrine connections · 2018Article
- Excess Body Weight, Insulin Resistance and Isolated Systolic Hypertension: Potential Pathophysiological Links.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2018Review
- Hemodynamic and Mechanical Properties of the Proximal Aorta in Young and Middle-Aged Adults With Isolated Systolic Hypertension: The Dallas Heart Study.Hypertension (Dallas, Tex. : 1979) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Young and middle-aged adults (ages ≤50 years) are increasingly prone to stroke, kidney disease, and worsening cardiovascular disease (CVD) mortality. An alarming increase in the prevalence of high blood pressure (BP) may underlie the adverse trend. However, there is often uncertainty in BP management for young and middle-aged adults. Isolated systolic hypertension (ISH) is one such example. Whether ISH in young and middle-aged adults represents "pseudo" or "spurious" hypertension is still being debated. ISH in young and middle-aged adults is a heterogeneous entity; some individuals appear to have increased stroke volume, whereas others have stiffened aortae, or both. One size does not seem to fit all in the clinical management of ISH in young and middle-aged adults. Rather than treating ISH as a monolithic condition, detailed phenotyping of ISH based on (patho)physiology and in the context of individual global cardiovascular risks would seem to be most useful to assess an individual expected net benefit from therapy. This review provides an overview of the current understanding of ISH in young and middle-aged adults, including the prevalence, pathophysiology, and treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.