Evidence map›Paper›PMID 27739007›Full record

ReviewCurrent obesity reports2016

Changes in Energy Expenditure with Weight Gain and Weight Loss in Humans.

Manfred J Müller, Janna Enderle, Anja Bosy-Westphal

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current obesity reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 6 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 6 syntheses or guidelines pooled it, 245 citations in OpenAlex.

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  6. Pooled it
  7. Effect of Time-Restricted Eating on Metabolic Adaptation in Adults With Severe Obesity During Early Phase of Weight Loss.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Manfred J MüllerInstitute of Human Nutrition and Food Science, Faculty of Agricultural and Nutritional Sciences, University of Kiel, Düsternbrooker Weg 17, D-24105, Kiel, Germany. mmueller@nutrfoodsc.uni-kiel.de.
Janna EnderleInstitute of Human Nutrition and Food Science, Faculty of Agricultural and Nutritional Sciences, University of Kiel, Düsternbrooker Weg 17, D-24105, Kiel, Germany.
Anja Bosy-WestphalInstitute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
Kiel University · DEUniversity of Hohenheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic adaptation to weight changes relates to body weight control, obesity and malnutrition. Adaptive thermogenesis (AT) refers to changes in resting and non-resting energy expenditure (REE and nREE) which are independent from changes in fat-free mass (FFM) and FFM composition. AT differs in response to changes in energy balance. With negative energy balance, AT is directed towards energy sparing. It relates to a reset of biological defence of body weight and mainly refers to REE. After weight loss, AT of nREE adds to weight maintenance. During overfeeding, energy dissipation is explained by AT of the nREE component only. As to body weight regulation during weight loss, AT relates to two different set points with a settling between them. During early weight loss, the first set is related to depleted glycogen stores associated with the fall in insulin secretion where AT adds to meet brain's energy needs. During maintenance of reduced weight, the second set is related to low leptin levels keeping energy expenditure low to prevent triglyceride stores getting too low which is a risk for some basic biological functions (e.g., reproduction). Innovative topics of AT in humans are on its definition and assessment, its dynamics related to weight loss and its constitutional and neuro-endocrine determinants.

Indexed as

Body CompositionDiet, ReducingEnergy MetabolismHumansObesityWeight GainWeight LossActivity-related energy expenditure (AEE)Adaptive thermogenesis (AT)Body compositionCaloric restrictionDiet-induced thermogenesis (DIT)Energy balanceEnergy expenditureExercise activity thermogenesis (EAT)Fat-free mass (FFM)Fat massInsulinLeptinMetabolic efficiencyNon-exercise activity thermogenesis (NEAT)ObesityOverfeedingResting energy expenditure (REE)SNS activityThyroid hormonesTotal body water (TBW)Total energy expenditure (TEE)Weight lossWeight maintenance

Identifiers

PMID27739007
PMCPMC5097076
OpenAlexW2531756294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.