Evidence map›Paper›PMID 27738994›Full record

ArticleBrain imaging and behavior2017

Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex.

Tulio Guadalupe, Samuel R Mathias, Theo G M vanErp, Christopher D Whelan, Marcel P Zwiers, Yoshinari Abe, Lucija Abramovic, Ingrid Agartz, Ole A Andreassen, Alejandro Arias-Vásquez and 151 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain imaging and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  3. Hemispheric asymmetries in borderline personality disorder: a systematic review.European archives of psychiatry and clinical neuroscience · 2025
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  7. [Research progress on genetic effects of the asymmetry of human brain structure revealed by magnetic resonance imaging].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020
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52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

161 authors.

Tulio GuadalupeLanguage & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
Samuel R MathiasDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, 06519, USA.
Theo G M vanErpDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
Christopher D WhelanImaging Genetics Center, Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA.
Marcel P ZwiersDonders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Yoshinari AbeDepartment of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Lucija AbramovicBrain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.
Ingrid AgartzNORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Ole A AndreassenNORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Alejandro Arias-VásquezDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
Benjamin S AribisalaDepartment of Computer Science, Lagos State University, Lagos, Nigeria.
Nicola J ArmstrongCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales (UNSW), Sydney, Australia.
Volker AroltDepartment of Psychiatry, University of Münster, Münster, Germany.
Eric ArtigesInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes -Sorbonne Paris Cité, Paris, France.
Rosa Ayesa-ArriolaDepartment of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
Vatche G BaboyanImaging Genetics Center, Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Los Angeles, USA.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany.
Gareth BarkerCentre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Mark E BastinBrain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.
Bernhard T BauneDiscipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, 5005, Australia.
John BlangeroDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neurosciences, Trinity College Dublin, Dublin, Ireland.
Premika S W BoedhoeDepartment of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands.
Anushree BoseDepartment of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
Silvia BremUniversity Clinic for and Adolescent Psychiatry UCCAP, University of Zurich, Zurich, Switzerland.
Henry BrodatyCentre for Healthy Brain Ageing (CHeBA), & Dementia Collaborative Research Centre, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.
Uli BrombergUniversity Medical Centre Hamburg-Eppendorf, House W34, 3.OG, Martinistr. 52, 20246, Hamburg, Germany.
Samantha BrooksDepartment of Psychiatry, University of Cape Town, Cape Town, South Africa.
Christian BüchelUniversity Medical Centre Hamburg-Eppendorf, House W34, 3.OG, Martinistr. 52, 20246, Hamburg, Germany.
Jan BuitelaarDepartment of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
Vince D CalhounDepartments of Electrical and Computer Engineering,Neurosciences, Computer Science, and Psychiatry, The University of New Mexico, Albuquerque, NM, USA.
Dara M CannonCentre for Neuroimaging, Cognition & Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine, Nursing and Health Sciences, National University of Ireland Galway, Galway, H91 TK33, Ireland.
Anna CattrellMedical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Yuqi ChengDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Patricia J ConrodDepartment of Psychiatry, Universite de Montreal, CHU Ste Justine Hospital, Montréal, Canada.
Annette ConzelmannDepartment of Psychology (Biological Psychology, Clinical Psychology, and Psychotherapy), University of Würzburg, Germany, Tübingen, Würzburg, Germany.
Aiden CorvinDepartment of Psychiatry, Trinity College Dublin, Dublin, Ireland.
Benedicto Crespo-FacorroDepartment of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
Fabrice CrivelloUMR5296 CNRS, CEA and University of Bordeaux, Bordeaux, France.
Udo DannlowskiDepartment of Psychiatry, University of Münster, Münster, Germany.
Greig I de ZubicarayFaculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane City, Australia.
Sonja M C de ZwarteBrain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK.
Sylvane DesrivièresMedical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Nhat Trung DoanNORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Gary DonohoeCognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition & Genomics Centre (NICOG), School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, SW4 794, Galway, Ireland.
Erlend S DørumNORMENT - KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Stefan EhrlichDepartment of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Dresden, Germany.
Thomas EspesethNORMENT - KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Guillén FernándezDepartment of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
Herta FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
Jean-Paul FoucheDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Vincent FrouinNeurospin, Commissariat à l'Energie Atomique, CEA-Saclay Center, Paris, France.
Masaki FukunagaDivision of Cerebral Integration, National Institute for Physiological Sciences, Okazaki, Japan.
Jürgen GallinatDepartment of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf (UKE), Martinistrasse 52, 20246, Hamburg, Germany.
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, VT, 05405, USA.
Michael GillDepartment of Psychiatry, Trinity College Dublin, Dublin, Ireland.
Andrea Gonzalez SuarezService of Neurology, University Hospital Marqués de Valdecilla (IDIVAL), University of Cantabria (UC), Santander, Spain.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.
Hans J GrabeDepartment of Psychiatry, University Medicine Greifswald, Greifswald, Germany.
Dominik GrotegerdDepartment of Psychiatry, University of Münster, Münster, Germany.
Oliver GruberCenter for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, D-37075, Göttingen, Germany.
Saskia HagenaarsCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Ryota HashimotoMolecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.
Tobias U HauserUniversity Clinic for Child and Adolescent Psychiatry (UCCAP), University of Zurich, Zurich, Switzerland.
Andreas HeinzDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.
Derrek P HibarImaging Genetics Center, Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA.
Pieter J HoekstraDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Martine HoogmanDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
Fleur M HowellsDepartment of Psychiatry, University of Cape Town, Cape Town, South Africa.
Hao HuShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, No. 600 Wan Ping Nan Road, Shanghai, 200030, China.
Hilleke E Hulshoff PolBrain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.
Chaim HuyserDe Bascule, Academic Center for Child and Adolescent Psychiatry, Amsterdam, The Netherlands.
Bernd IttermannPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.
Neda JahanshadImaging Genetics Center, Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Los Angeles, USA.
Erik G JönssonDepartment of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden.
Sarah JurkDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Rene S KahnBrain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.
Sinead KellyImaging Genetics Center, Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Los Angeles, 90292, USA.
Bernd KraemerCenter for Translational Research in Systems Neuroscience and Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, D-37075, Göttingen, Germany.
Harald KugelDepartment of Clinical Radiology, University of Münster, Münster, Germany.
Jun Soo KwonDepartment of Psychiatry & Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea.
Herve LemaitreInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes -Sorbonne Paris Cité, Paris, France.
Klaus-Peter LeschDivision of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany.
Christine LochnerDepartment of Psychiatry, University of Stellenbosch and MRC Unit on Anxiety & Stress Disorders, Tygerberg, Cape Town, South Africa.
Michelle LucianoCentre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh, UK.
Andre F MarquandDonders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Ignacio Martínez-ZalacaínDepartment of Psychiatry, Bellvitge University Hospital - Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes - Sorbonne Paris Cité, and Maison de Solenn, Paris, France.
David Mataix-ColsDepartment of Clinical Neuroscience,Centre for Psychiatric Research and Education, Karolinska Institutet, Stockholm, Sweden.
Karen MatherCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales (UNSW), Sydney, Australia.
Colm McDonaldCentre for Neuroimaging, Cognition & Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine, Nursing and Health Sciences, National University of Ireland Galway, Galway, H91 TK33, Ireland.
Katie L McMahonCentre for Advanced Imaging, University of Queensland, Brisbane, Australia.
Sarah E MedlandQIMR Berghofer Medical Research Institute, Brisbane, Australia.
José M MenchónDepartment of Psychiatry, Bellvitge University Hospital - Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.
Derek W MorrisCognitive Genetics and Cognitive Therapy Group, Neuroimaging, Cognition & Genomics Centre (NICOG), School of Psychology and Discipline of Biochemistry, National University of Ireland Galway, SW4 794, Galway, Ireland.
Omar MothersillDepartment of Psychiatry, Trinity College Dublin, Dublin, Ireland.
Susana Munoz ManiegaBrain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.
Benson MwangiUT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, UT Houston Medical School, Houston, TX, USA.
Takashi NakamaeDepartment of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Tomohiro NakaoDepartment of Neuropsychiatry, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Janardhanan C NarayanaswaamyDepartment of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
Frauke NeesDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
Jan E NordvikSunnaas Rehabilitation Hospital HT, Nesodden, Norway.
A Marten H OnninkDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
Nils OpelDepartment of Psychiatry, University of Münster, Münster, Germany.
Roel OphoffBrain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes -Sorbonne Paris Cité, Paris, France.
Dimitri Papadopoulos OrfanosNeurospin, Commissariat à l'Energie Atomique, CEA-Saclay Center, Paris, France.
Paul PauliDepartment of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany.
Tomáš PausRotman Research Institute, Baycrest and Departments of Psychology and Psychiatry, University of Toronto, M6A 2E1, Toronto, ON, Canada.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany.
Janardhan Yc ReddyDepartment of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
Miguel E RenteriaQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Roberto Roiz-SantiáñezDepartment of Psychiatry, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria-IDIVAL, Santander, Spain.
Annerine RoosDepartment of Psychiatry, University of Stellenbosch and MRC Unit on Anxiety & Stress Disorders, Tygerberg, Cape Town, South Africa.
Natalie A RoyleBrain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.
Perminder SachdevCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales (UNSW), Sydney, Australia.
Pascual Sánchez-JuanService of Neurology, University Hospital Marqués de Valdecilla (IDIVAL), University of Cantabria (UC), Santander, Spain.
Lianne SchmaalDepartment of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Gunter SchumannMedical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Elena ShumskayaDonders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Jair C SoaresDepartment of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, 77054, USA.
Carles Soriano-MasDepartment of Psychiatry, Bellvitge University Hospital - Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), Barcelona, Spain.
Dan J SteinDepartment of Psychiatry, University of Cape Town and MRC Unit on Anxiety & Stress Disorders, Cape Town, South Africa.
Lachlan T StrikeQueensland Brain Institute, The University of Queensland, Brisbane, Australia.
Roberto ToroLaboratory of Human Genetics and Cognitive Functions, Institut Pasteur, 75015, Paris, France.
Jessica A TurnerThe Mind Research Network, Albuquerque, NM, USA.
Nathalie Tzourio-MazoyerUMR5296 CNRS, CEA and University of Bordeaux, Bordeaux, France.
Anne UhlmannDepartment of Psychiatry and Mental Health, University of Cape Town, Observatory, Cape Town, South Africa.
Maria Valdés HernándezBrain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.
Odile A van den HeuvelDepartment of Anatomy & Neurosciences, VU University Medical Center, Amsterdam, The Netherlands.
Dennis van der MeerDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Neeltje E M van HarenBrain Centre Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands.
Dick J VeltmanDepartment of Psychiatry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Ganesan VenkatasubramanianDepartment of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
Nora C VetterDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Daniella VuleticDepartment of Psychiatry, University of Cape Town, Cape Town, South Africa.
Susanne WalitzaUniversity Clinic for Child and Adolescent Psychiatry (UCCAP), University of Zurich, Zurich, Switzerland.
Henrik WalterDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Charitéplatz 1, Berlin, Germany.
Esther WaltonDepartment of Child and Adolescent Psychiatry, Faculty of Medicine of the TU Dresden, Dresden, Germany.
Zhen WangShanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, No. 600 Wan Ping Nan Road, Shanghai, 200030, China.
Joanna WardlawBrain Research Imaging Centre, University of Edinburgh, Edinburgh, UK.
Wei WenCentre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales (UNSW), Sydney, Australia.
Lars T WestlyeNORMENT - KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Robert WhelanDepartment of Psychology, University College Dublin, Dublin, Ireland.
Katharina WittfeldGerman Center for Neurodegenerative Diseases (DZNE), Site Rostock, Greifswald, Germany.
Thomas WolfersDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
Margaret J WrightQIMR Berghofer Medical Research Institute, Brisbane, Australia.
Jian XuDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Xiufeng XuDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Je-Yeon YunSeoul National University Hospital, Seoul, Republic of Korea.
JingJing ZhaoCognitive Genetics and Therapy Group, School of Psychology & Discipline of Biochemistry, National University of Ireland Galway, Galway, SW4 794, Ireland.
Barbara FrankeDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, The Netherlands.
Paul M ThompsonImaging Genetics Center, Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Marina del Rey, CA, USA.
David C GlahnDepartment of Psychiatry, Yale University, New Haven, CT, 06511, USA.
Bernard MazoyerUMR5296 CNRS, CEA and University of Bordeaux, Bordeaux, France.
Simon E FisherLanguage & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
Clyde FrancksLanguage & Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands. clyde.francks@mpi.nl.

Funding

HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Genomic Studies of Bipolar Disorder in a Large Cohort from The NetherlandsR01MH090553 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OPHOFF, ROEL A · 2010 to 2014
$6.0M
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
Genetics of Brain Structure and FunctionR01MH078111 · NIMH · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI BLANGERO, JOHN · 2006 to 2014
$4.5M
Genetics of Brain Structure and Function: Genome-Wide AssociationR01MH083824 · NIMH · YALE UNIVERSITY · PI GLAHN, DAVID C · 2008 to 2013
$3.3M
PHYSICIAN-INVESTIGATOR DEVELOPMENT AWARD PROGRAMK08CA001245 · NCI · UNIVERSITY OF LOUISVILLE · PI HEUSER, LOUIS S · 1986 to 1986
–
Medical Research Council G0701120Medical Research Council G1001245Medical Research Council MC_UU_12013/1Medical Research Council MC_UU_12013/2Medical Research Council MR/K026992/1Medical Research Council MR/M013111/1NCRR NIH HHS UL1 RR025758NIBIB NIH HHS R01 EB015611NIBIB NIH HHS U54 EB020403NIMH NIH HHS R01 MH078111NIMH NIH HHS R01 MH083824NIMH NIH HHS R01 MH090553
6 · The paper itself

Abstract

The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.

Indexed as

Functional LateralitySex CharacteristicsAdolescentAdultAgedAgingBrainFemaleHumansMagnetic Resonance ImagingMaleMeta-Analysis as TopicMiddle AgedOrgan SizeQuantitative Trait, HeritableYoung AdultAgeEnigmaHandednessHeritabilityMeta-analysisSexSubcortical brain asymmetry

Identifiers

PMID27738994
PMCPMC5540813

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