ArticleStem cell reviews and reports2017
A Regenerative Approach with Dermal Micrografts in the Treatment of Chronic Ulcers.
Article in Stem cell reviews and reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04030832 (Reconstruction of Skin Substance Loss With Method of "Micro-grafts" Obtained by Mechanical Disintegration), which is not on this map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reconstruction of Skin Substance Loss With Method of "Micro-grafts" Obtained by Mechanical Disintegration: Preliminary Study
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Systematic review and meta-analysis of the use of micrografting technology in humans.The Journal of international medical research · 2025Pooled it
- Autologous cutis and subcutis micrografts combined with a collagen-elastin dermal scaffold for chronic wounds: a retrospective single-arm clinical study with prospectively collected data.Frontiers in pharmacology · 2026Article
- Applications of Adipose Tissue Micrografts (ATM) and Dermis Micrografts (DMG) in Wound Healing: A Scoping Review of Clinical Studies.Bioengineering (Basel, Switzerland) · 2025Review
- Skin Micro-Fragments for the Management of Diabetic Foot Ulcers: A Case Series.The international journal of lower extremity wounds · 2025Article
- Efficacy and Safety of an Autologous Micrografting Procedure for Management of Striae Distensae in Women.Dermatology and therapy · 2024Article
- Mesenchymal stem cells-based drug delivery systems for diabetic foot ulcer: A review.World journal of diabetes · 2023Review
- Prospective Observational Study of a Non-Arthroscopic Autologous Cartilage Micrografting Technology for Knee Osteoarthritis.Bioengineering (Basel, Switzerland) · 2023Article
- Stem cell and tissue engineering approaches in pressure ulcer treatment.The journal of spinal cord medicine · 2023Review
- Comparison of Wound Healing Effect of Skin Micrograft Impregnated into Two Kinds of Artificial Dermis in a Murine Wound Model.Plastic and reconstructive surgery. Global open · 2022Article
- Scaffold-based delivery of mesenchymal stromal cells to diabetic wounds.Stem cell research & therapy · 2022Review
- Novel Technologies in Chronic Wound Care.Seminars in plastic surgery · 2022Review
- A Histological Evaluation of Artificial Dermal Scaffold Used in Micrograft Treatment: A Case Study of Micrograft and NPWT Performed on a Postoperative Ulcer Formation after Tumor Resection.Medicina (Kaunas, Lithuania) · 2022Article
- In Vitro Characterization of Canine Microfragmented Adipose Tissue Non-Enzymatically Extracted from the Thigh and Lumbar Regions.Animals : an open access journal from MDPI · 2021Article
- Use of micro-grafts in a chronic infected open wound after limb amputation in a cat.Veterinarni medicina · 2021Article
- Cartilage Micrografts as a Novel Non-Invasive and Non-Arthroscopic Autograft Procedure for Knee Chondropathy: Three-Year Follow-Up Study.Journal of clinical medicine · 2021Article
- Why Venous Leg Ulcers Have Difficulty Healing: Overview on Pathophysiology, Clinical Consequences, and Treatment.Journal of clinical medicine · 2020Review
- Evaluation of Bone Regeneration in Rat Calvaria Using Bone Autologous Micrografts and Xenografts: Histological and Histomorphometric Analysis.Materials (Basel, Switzerland) · 2020Article
- Acceleration of Skin Wound-Healing Reactions by Autologous Micrograft Tissue Suspension.Medicina (Kaunas, Lithuania) · 2020Article
- In Vitro Characterization of Adipose Stem Cells Non-Enzymatically Extracted from the Thigh and Abdomen.International journal of molecular sciences · 2020Article
- A case report on the effect of micrografting in the healing of chronic and complex burn wounds.International journal of burns and trauma · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe etiology of non-healing ulcers depends on both systemic and local factors. The introduction of advanced dressing, negative wound therapy and compression therapy have undoubtedly improved clinical outcomes. The principal aim of study was to demonstrate the efficacy of dermal micrografts in the treatment of ulcers with different etiologies. The second aim was to investigate in vitro the action of micrografts in the regenerative process.
methodsThe dermal micro-grafts were obtained from mechanical disaggregation of small pieces of skin tissue through a medical device called Rigeneracons.
resultsWe observed in vivo the ability of dermal autologous micrografts to improve the healing of venous, diabetic, pressure and post-traumatic ulcers after few week of treatment accomplished in general with a better quality of life for the patients. In vitro results showed that these micrografts express mesenchymal stem cells (MSCS) marker such as CD34, CD73, CD90 and CD105, and are able to form a viable and proliferative biocomplex with collagen sponge. Finally, the site of ulcers displayed a different expression of epidermal growth factors, insulin-like growth factors, platelet-derived growth factors and their receptors and tumor necrosis factor-β with respect to healthy skin samples.
conclusionWe reported a good outcome for the treatment of chronic ulcers using dermal autologous micrografts. Finally, we suggest that the positivity to MSCs markers and the ability to interact with a scaffold can play a key role in their regenerative properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.